{"id":"W3216904671","doi":"10.1101/2021.11.19.21265383","title":"GWAS defines pathogenic signaling pathways and prioritizes drug targets for IgA nephropathy","year":2021,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Toronto General Hospital; University of Toronto","funders":"Medical Research Council; Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu; Albert-Ludwigs-Universität Freiburg; Bundesministerium für Bildung und Forschung; National Natural Science Foundation of China; Deutsche Forschungsgemeinschaft; National Institute of Diabetes and Digestive and Kidney Diseases; Medizinische Fakultät der Albert-Ludwigs-Universität Freiburg; Všeobecná Fakultní Nemocnice v Praze; Amgen; National Science Foundation; Kidney Research UK; KfH-Stiftung Präventivmedizin; Fresenius Medical Care North America; U.S. Department of Veterans Affairs","keywords":"Genome-wide association study; Nephropathy; Biology; Immunology; SNP; Disease; Genetic association; Candidate gene; Genetics; Single-nucleotide polymorphism; Gene; Medicine; Internal medicine; Genotype; Endocrinology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000977106,0.0005412396,0.001176471,0.001165499,0.0002848822,0.0009308121,0.0003079145,0.0005409659,0.004298639],"category_scores_gemma":[0.001636437,0.0001708065,0.001203623,0.002024501,0.0002270014,0.0002268266,0.000389768,0.0005594675,0.0003909403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002634231,"about_ca_system_score_gemma":0.0004382686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001044201,"about_ca_topic_score_gemma":0.001910504,"domain_scores_codex":[0.9994155,0.0002254142,0.00005149713,0.0001358483,0.0001037508,0.00006800617],"domain_scores_gemma":[0.9990797,0.0004474623,0.000259412,0.00005548499,0.00006433592,0.00009361454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004908029,0.0002892521,0.8311941,0.0006430913,0.005822764,0.001360602,0.00008914629,0.003023446,0.05227663,0.001076817,0.005038365,0.0942777],"study_design_scores_gemma":[0.0006480253,0.001182469,0.9582992,0.0001428229,0.005747319,0.002065298,0.0001858331,0.009339591,0.007522392,0.002812906,0.01200599,0.00004808063],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9621666,0.02242438,0.005133167,0.001975874,0.0001709812,0.00009712093,0.00376171,0.0003261595,0.003943972],"genre_scores_gemma":[0.9936476,0.001990726,0.001774502,0.000522745,0.00007704366,0.00002459588,0.001409082,0.00003214391,0.0005215475],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004298639,"threshold_uncertainty_score":0.01438034,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0224918601499807,"score_gpt":0.2623238096429473,"score_spread":0.2398319494929666,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}