{"id":"W3216921237","doi":"10.1002/ange.202113235","title":"Template‐Directed Synthesis of Bivalent, Broad‐Spectrum Hosts for Neuromuscular Blocking Agents**","year":2021,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Supramolecular Chemistry and Complexes","field":"Chemistry","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Canada's Michael Smith Genome Sciences Centre; University of Victoria","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Combinatorial chemistry; Supramolecular chemistry; Broad spectrum; Bivalent (engine); Neuromuscular Blocking Agents; Amine gas treating; Organic chemistry; Molecule; Metal","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00009165925,0.0002953445,0.0004307973,0.00003535669,0.0001229779,0.00004571407,0.0003276324,0.0001942401,0.001665068],"category_scores_gemma":[0.0004924135,0.0003274857,0.0004064196,0.0002576897,0.00007571536,0.00006414606,0.0001357878,0.00016918,0.000006596628],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000488639,"about_ca_system_score_gemma":0.00009195881,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002209106,"about_ca_topic_score_gemma":0.000005364062,"domain_scores_codex":[0.9983027,0.00001799598,0.0003893819,0.0005604474,0.0002875931,0.0004418903],"domain_scores_gemma":[0.9985671,0.0002811549,0.0001819401,0.0007014148,0.0001382029,0.0001301887],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004859142,0.0001594064,0.0007984496,0.0006906432,0.0002487123,0.000132356,0.00006830819,0.000007590564,0.9953017,0.00002588799,0.002082175,0.0004362158],"study_design_scores_gemma":[0.0005819944,0.000009740822,0.00009889635,0.0002051607,0.0001861233,0.00009433972,0.0001213451,0.00005060429,0.9759316,0.0002313372,0.0221538,0.0003350443],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9754665,0.001412215,0.0001208,0.000319554,0.0001133434,0.00009716667,0.000188543,0.0002489664,0.02203292],"genre_scores_gemma":[0.9968079,0.0001145862,0.0006393815,0.0001016967,0.0002162504,0.00008585698,0.0001870022,0.00006676461,0.001780519],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02134145,"threshold_uncertainty_score":0.9999177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02490002648285464,"score_gpt":0.2518494603218301,"score_spread":0.2269494338389755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}