{"id":"W3216956782","doi":"10.1182/blood-2021-154729","title":"The POLARIX Study: Polatuzumab Vedotin with Rituximab, Cyclophosphamide, Doxorubicin, and Prednisone (pola-R-CHP) Versus Rituximab, Cyclophosphamide, Doxorubicin, Vincristine and Prednisone (R-CHOP) Therapy in Patients with Previously Untreated Diffuse Large B-Cell Lymphoma","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Roche (Canada); Sunnybrook Health Science Centre; Health Sciences Centre; Spinal Cord Injury BC; University of British Columbia","funders":"","keywords":"Medicine; Rituximab; Vincristine; Internal medicine; Prednisone; International Prognostic Index; Cyclophosphamide; Diffuse large B-cell lymphoma; Clinical endpoint; Gastroenterology; Placebo; Bendamustine; Surgery; Oncology; Chemotherapy; Lymphoma; Clinical trial; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002088581,0.001463224,0.001757816,0.0003281216,0.0002361459,0.001125141,0.0008572261,0.001099638,0.00431258],"category_scores_gemma":[0.0009011136,0.0005125536,0.001445493,0.0003838854,0.001063391,0.0009162657,0.0004962906,0.002951424,0.0006431748],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008232127,"about_ca_system_score_gemma":0.0009679091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008455669,"about_ca_topic_score_gemma":0.001332375,"domain_scores_codex":[0.9994333,0.0003561321,0.00002481492,0.00007771741,0.00004225011,0.00006575529],"domain_scores_gemma":[0.999143,0.0002399543,0.0001987294,0.00005707644,0.00004296538,0.0003182545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9817593,0.004443014,0.0007650157,0.0002376828,0.0004943107,0.00002671485,0.00003190745,0.0002971262,0.003240783,0.00007004789,0.0003940493,0.008240053],"study_design_scores_gemma":[0.8220947,0.1719623,0.003144081,0.00003511864,0.0006322079,0.00004565432,0.00003273167,0.0003914559,0.0007698263,0.00009797973,0.0007815597,0.00001237353],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910887,0.003958915,0.0003302642,0.0004215182,0.0003333792,0.001022671,0.0006370164,0.00004693569,0.002160511],"genre_scores_gemma":[0.9914222,0.002338196,0.0005595027,0.0007092198,0.0004640637,0.001046779,0.001252974,0.00001465861,0.002192298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00431258,"threshold_uncertainty_score":0.01442701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004783608112453132,"score_gpt":0.2093766557687433,"score_spread":0.2045930476562901,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}