{"id":"W3216974135","doi":"10.1038/s41598-021-02339-3","title":"Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts","year":2021,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Aryl hydrocarbon receptor; Protein kinase B; PI3K/AKT/mTOR pathway; Phosphorylation; Cell biology; Biology; Chemistry; Signal transduction; Cancer research; Biochemistry; Transcription factor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006341113,0.00009845558,0.0001081907,0.00002347407,0.000156296,0.00005510776,0.0001355206,0.00007835067,0.0000428294],"category_scores_gemma":[0.00008269427,0.00006615089,0.0001195451,0.0003070134,0.0001440663,0.000003787452,0.0001694297,0.00007103259,0.000001010129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003061758,"about_ca_system_score_gemma":0.0002473909,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004486092,"about_ca_topic_score_gemma":0.0001923307,"domain_scores_codex":[0.9986161,0.00007431093,0.0003417541,0.0004653651,0.0003121611,0.0001903118],"domain_scores_gemma":[0.9987051,0.00000987066,0.0002109103,0.000932757,0.0001071575,0.0000341482],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000006048949,0.00005250269,0.00408906,0.00001366174,0.00001251742,0.00001041573,0.0001155871,0.0002397276,0.9884602,0.00001289535,0.006484069,0.0005032925],"study_design_scores_gemma":[0.00008783542,0.00001878433,0.003102212,0.00002129012,0.000007055827,0.0001204083,0.00007963878,0.00008047147,0.973995,0.000219163,0.02218819,0.00007998681],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960124,0.001015659,0.00005644808,0.0002230616,0.001398672,0.000249511,0.00001225121,0.000003727951,0.001028229],"genre_scores_gemma":[0.9967496,0.00001107476,0.00005473892,0.00004071163,0.00005235498,0.00001541834,0.0001576081,0.000009490829,0.002908945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01570412,"threshold_uncertainty_score":0.2697555,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008437149561519053,"score_gpt":0.214812385785587,"score_spread":0.2063752362240679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}