{"id":"W3216983312","doi":"10.1101/2021.11.30.470443","title":"De Novo Pyrimidine Synthesis is a Targetable Vulnerability in IDH Mutant Glioma","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Ludwig Center at Harvard; National Institutes of Health; Wellcome Trust; Memorial Sloan-Kettering Cancer Center; University of Texas Southwestern Medical Center; V Foundation for Cancer Research; Dana-Farber Cancer Institute; Sontag Foundation; Howard Hughes Medical Institute; Cancer Prevention and Research Institute of Texas; University of California, San Francisco; Pediatric Brain Tumor Foundation","keywords":"Isocitrate dehydrogenase; Dihydroorotate dehydrogenase; Glioma; Mutant; Pyrimidine metabolism; IDH1; Biology; Cancer research; Purine; Pyrimidine; Enzyme; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001410779,0.0002741479,0.0002829422,0.0003104234,0.0001187205,0.0004373647,0.0001462411,0.0003232167,0.001677926],"category_scores_gemma":[0.0001210362,0.0001340289,0.0001739713,0.0001731442,0.0002639682,0.0001439246,0.0002311791,0.0004657904,0.000369231],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002917372,"about_ca_system_score_gemma":0.0001871875,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004955206,"about_ca_topic_score_gemma":0.000542219,"domain_scores_codex":[0.9999204,0.00000807574,0.000006189063,0.00002042078,0.00002855199,0.00001626485],"domain_scores_gemma":[0.9999288,0.00001458827,0.00002384061,0.000009093133,0.000007371411,0.0000162975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001352021,0.00002009705,0.001884924,0.00004090148,0.000008023749,0.0002833004,0.00001594339,0.0002633719,0.9921612,0.0004302782,0.000216972,0.004539809],"study_design_scores_gemma":[0.00001334443,0.0001898474,0.008591512,0.000004107958,0.00001880332,0.002141363,0.00002564126,0.001201341,0.9832762,0.0004849221,0.004047266,0.000005598102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862787,0.00260316,0.006150324,0.0004447399,0.0000402054,0.00003130433,0.00074915,0.0003000005,0.003402408],"genre_scores_gemma":[0.9949131,0.000820117,0.002083178,0.00008493296,0.00001264018,0.00001046663,0.0004820529,0.00003131582,0.001562088],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001677926,"threshold_uncertainty_score":0.005613208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01776950133679082,"score_gpt":0.2451461860193691,"score_spread":0.2273766846825783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}