{"id":"W3217057953","doi":"10.1016/j.chom.2021.12.004","title":"Strong humoral immune responses against SARS-CoV-2 Spike after BNT162b2 mRNA vaccination with a 16-week interval between doses","year":2021,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":113,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institut National de Santé Publique du Québec; Héma-Québec; University of Ottawa; McGill University Health Centre; Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"Fonds de Recherche du Québec - Santé; Institute of Infection and Immunity; Mitacs; Canadian Institutes of Health Research; Fondation du CHUM; Canada Foundation for Innovation; Public Health Agency of Canada","keywords":"Immune system; Regimen; Vaccination; Immunology; Vaccine efficacy; Flexibility (engineering); Biology; Medicine; Messenger RNA; Virology; Internal medicine; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004274257,0.0004261242,0.0006731767,0.0003588294,0.0001561399,0.0001837625,0.0003092918,0.0002018745,0.00009806974],"category_scores_gemma":[0.0001367921,0.0003722235,0.0002690628,0.000641732,0.000141752,0.0002466344,0.0003239306,0.0006902958,0.0002852918],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004065429,"about_ca_system_score_gemma":0.0007125434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002704937,"about_ca_topic_score_gemma":0.0002622782,"domain_scores_codex":[0.9971658,0.0002293627,0.0005661235,0.0007381227,0.0005262138,0.0007743832],"domain_scores_gemma":[0.9983087,0.0001984736,0.0001629616,0.0007828362,0.0004710961,0.00007595558],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002148233,0.0004815759,0.08677748,0.0002863078,0.0001403247,0.00109029,0.0006296388,1.259039e-7,0.903578,0.000005648847,0.0009320672,0.003930278],"study_design_scores_gemma":[0.003060808,0.0007398712,0.08289707,0.0003506937,0.0001484102,0.00008666758,0.0005034842,0.00000948281,0.8569497,0.00001014418,0.0548875,0.0003561865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907787,0.003275856,0.0003629351,0.0005728764,0.0001550564,0.0005398709,0.00006715136,0.000115411,0.004132117],"genre_scores_gemma":[0.9886372,0.00002738562,0.0006036697,0.009018546,0.0003588736,0.00006296688,0.00009777775,0.0001011395,0.001092416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05395543,"threshold_uncertainty_score":0.999873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03750498156267176,"score_gpt":0.3250527890378279,"score_spread":0.2875478074751561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}