{"id":"W3217067446","doi":"10.3390/cancers13225830","title":"Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Merck Sharp and Dohme; AstraZeneca","keywords":"Olaparib; Medicine; Prostate cancer; Oncology; Abiraterone; Internal medicine; PARP inhibitor; Germline; Homologous recombination; Germline mutation; Cancer; Cancer research; CHEK2; Urology; Mutation; Biology; Genetics; Androgen receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002320192,0.0001513259,0.0003761049,0.0001509049,0.00007389617,0.00001648777,0.00003075617,0.00006331343,0.00007344687],"category_scores_gemma":[0.00005237425,0.0001360199,0.00005146052,0.0004508874,0.0001115089,0.0001561349,0.00002367516,0.000121257,7.34858e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009959055,"about_ca_system_score_gemma":0.001364575,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007516338,"about_ca_topic_score_gemma":0.0001385634,"domain_scores_codex":[0.9986388,0.0001092329,0.0004216633,0.0003533585,0.000227233,0.0002496989],"domain_scores_gemma":[0.9992967,0.00002392648,0.0001831205,0.0001574499,0.0002365255,0.0001022617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.05700608,0.0005199245,0.0002144561,0.0003355338,0.0001836443,0.0003682075,0.00151156,0.00002543583,0.9309534,0.00001286991,0.00009994061,0.008768909],"study_design_scores_gemma":[0.1622057,0.01192962,0.002405469,0.0004472408,0.0003194707,0.00007840725,0.0006613378,0.001597452,0.8194113,0.00005313336,0.0005962378,0.0002946751],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952068,0.002277159,0.00003460101,0.0007304654,0.0002218314,0.001096818,0.000361198,0.0000321978,0.00003894512],"genre_scores_gemma":[0.9937713,0.002992689,0.0001741252,0.0000588381,0.00003721375,0.0004195444,0.001378933,0.00002319647,0.00114421],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1115422,"threshold_uncertainty_score":0.554673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805803490488196,"score_gpt":0.3331128205273476,"score_spread":0.3050547856224656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}