{"id":"W3217067446","doi":"10.3390/cancers13225830","title":"Homologous Recombination Repair Gene Mutation Characterization by Liquid Biopsy: A Phase II Trial of Olaparib and Abiraterone in Metastatic Castrate-Resistant Prostate Cancer","year":2021,"lang":"en","type":"article","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Merck Sharp and Dohme; AstraZeneca","keywords":"Olaparib; Medicine; Prostate cancer; Oncology; Abiraterone; Internal medicine; PARP inhibitor; Germline; Homologous recombination; Germline mutation; Cancer; Cancer research; CHEK2; Urology; Mutation; Biology; Genetics; Androgen receptor; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002046659,0.001307177,0.001548697,0.0004623014,0.0003794296,0.0008002666,0.0008558371,0.0009951423,0.003417734],"category_scores_gemma":[0.001717598,0.0005711401,0.00083355,0.0004673621,0.0008910478,0.0005998877,0.0004220126,0.002899468,0.0006589985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008931383,"about_ca_system_score_gemma":0.001641523,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001117715,"about_ca_topic_score_gemma":0.001817299,"domain_scores_codex":[0.9991307,0.0004963299,0.00004315754,0.0001263479,0.0001052136,0.00009844249],"domain_scores_gemma":[0.9987996,0.0002349603,0.0002263096,0.0001039326,0.00008632742,0.0005488365],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8099385,0.04843098,0.008123294,0.0004943686,0.0007126366,0.000195996,0.0003090294,0.00105108,0.0350944,0.0001260915,0.001247423,0.09427624],"study_design_scores_gemma":[0.585053,0.3931602,0.01455453,0.0000315273,0.000296292,0.0004483789,0.00006444548,0.001117052,0.003906959,0.0001358551,0.001202718,0.00002903974],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959727,0.001111298,0.0003442338,0.0002234562,0.00004851557,0.001368237,0.0003436762,0.00005240049,0.0005355036],"genre_scores_gemma":[0.9934503,0.0007678138,0.00155361,0.000497514,0.0001182053,0.001568103,0.0009841296,0.00001658914,0.001043793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003417734,"threshold_uncertainty_score":0.01143342,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02805803490488196,"score_gpt":0.3331128205273476,"score_spread":0.3050547856224656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}