{"id":"W3217067747","doi":"10.1093/femsml/uqab013","title":"Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics","year":2021,"lang":"en","type":"article","venue":"microLife","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Histone; Epigenetics; Biology; Acetylation; Chromatin; Histone-modifying enzymes; Histone Acetyltransferases; Histone deacetylase; Cell biology; Chromatin remodeling; Genetics; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001702567,0.0001725164,0.0002214561,0.00005068146,0.00008213348,0.0000159899,0.0001352092,0.0001792799,0.00005590724],"category_scores_gemma":[0.0001409386,0.0001816416,0.0001010156,0.0001096792,0.0002205059,0.000002376464,0.0001967585,0.0001148008,0.00002481895],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002300956,"about_ca_system_score_gemma":0.0002714412,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002671116,"about_ca_topic_score_gemma":0.00005149404,"domain_scores_codex":[0.9986915,0.0001296502,0.000273664,0.0004053118,0.0001950994,0.0003047498],"domain_scores_gemma":[0.9990485,0.00002392344,0.00007919987,0.0004587762,0.0002613788,0.0001282001],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004735197,0.0001156964,0.001263794,0.0000407369,0.00005778415,0.00004394705,0.0001551228,0.000005641626,0.9947395,0.00002735259,0.001477753,0.002025357],"study_design_scores_gemma":[0.0004169213,0.0001733134,0.00060542,0.00001394207,0.00002236836,0.0001058869,0.0001074616,0.000008572897,0.8697479,0.00002952288,0.1286035,0.0001651389],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9727211,0.02566375,0.0002997501,0.0002332475,0.00009548908,0.0001154079,0.00009277532,0.000008130232,0.000770351],"genre_scores_gemma":[0.9918524,0.003062114,0.001863251,0.0005576674,0.0001629159,0.0000125573,0.0001406434,0.00004352835,0.002304913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1271258,"threshold_uncertainty_score":0.740713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116304339051865,"score_gpt":0.2941315699344416,"score_spread":0.2825011360292551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}