{"id":"W3217067747","doi":"10.1093/femsml/uqab013","title":"Patho-epigenetics: histone deacetylases as targets of pathogens and therapeutics","year":2021,"lang":"en","type":"article","venue":"microLife","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de la Recherche; Fondation de la recherche en santé du Nouveau-Brunswick","keywords":"Histone; Epigenetics; Biology; Acetylation; Chromatin; Histone-modifying enzymes; Histone Acetyltransferases; Histone deacetylase; Cell biology; Chromatin remodeling; Genetics; Computational biology; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006403667,0.0008049299,0.0007884248,0.001081833,0.0003935767,0.001477856,0.0007083683,0.001319683,0.006154056],"category_scores_gemma":[0.000466109,0.0002602237,0.0003870661,0.0010265,0.0009017225,0.00153372,0.0009341714,0.002477141,0.003636518],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001198507,"about_ca_system_score_gemma":0.0008754085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005183682,"about_ca_topic_score_gemma":0.001182935,"domain_scores_codex":[0.9996758,0.00005918884,0.00001805362,0.00006647194,0.0001327772,0.00004786758],"domain_scores_gemma":[0.9997848,0.000052976,0.00003157829,0.00001277802,0.00006819069,0.00004970839],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003614516,0.0001959024,0.0005966095,0.006272195,0.0001123551,0.0005102644,0.0002214652,0.000795627,0.05717171,0.054366,0.06713271,0.8122636],"study_design_scores_gemma":[0.00002828563,0.000212701,0.0004728694,0.0003699597,0.00004161019,0.0007231187,0.0000592897,0.0002304364,0.01057134,0.008076776,0.9791914,0.00002223303],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001925359,0.9708834,0.005041778,0.005374163,0.002507219,0.0000400529,0.0001730486,0.0001832685,0.01387177],"genre_scores_gemma":[0.02237353,0.9465074,0.004051529,0.003047803,0.002156019,0.00009050103,0.0003082629,0.00004663524,0.02141842],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.006154056,"threshold_uncertainty_score":0.02058738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0116304339051865,"score_gpt":0.2941315699344416,"score_spread":0.2825011360292551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}