{"id":"W3217086539","doi":"10.1371/journal.pone.0259313","title":"Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Toronto Metropolitan University; University of Toronto","funders":"Canada Research Chairs; Government of Ontario; Canada Foundation for Innovation; Ryerson University","keywords":"Lysosome; Reactive oxygen species; Chemistry; Coalescence (physics); Oxygen; Cell biology; Biophysics; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007777894,0.0001155838,0.0001600409,0.00002658845,0.00008767602,0.00002654423,0.00006403495,0.00008355254,0.00007292431],"category_scores_gemma":[0.0001221541,0.0001258076,0.00007665051,0.00009699457,0.00004547239,0.000004963243,0.0001122526,0.00009884116,0.0000319436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001923622,"about_ca_system_score_gemma":0.00004632496,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005032953,"about_ca_topic_score_gemma":0.00000886978,"domain_scores_codex":[0.9990755,0.00006008151,0.0001545958,0.0003252541,0.0001944939,0.0001901115],"domain_scores_gemma":[0.9994444,0.000008038674,0.00006108994,0.0002744943,0.0001422912,0.00006972542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004480671,0.0005782991,0.0006944447,0.00004438749,0.0001124496,0.00002120303,0.00006514415,0.000004234686,0.998237,0.00005627983,0.0001013488,0.00004042851],"study_design_scores_gemma":[0.0003291066,0.00004542426,0.01093371,0.0001167707,0.00006503029,0.00001279442,0.00007606167,0.000006745689,0.9876243,0.00006308152,0.000569132,0.0001578248],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971632,0.00121404,0.00006662119,0.0002576354,0.00004874808,0.0001030882,0.00002809466,0.00002183503,0.001096755],"genre_scores_gemma":[0.9942377,0.000432658,0.0005959474,0.0001256418,0.000490615,0.00001589611,0.0001649539,0.00002039534,0.003916167],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01061265,"threshold_uncertainty_score":0.5130286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0255644367065177,"score_gpt":0.2138599013345283,"score_spread":0.1882954646280106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}