{"id":"W3217086539","doi":"10.1371/journal.pone.0259313","title":"Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition","year":2021,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network; Toronto Metropolitan University; University of Toronto","funders":"Canada Research Chairs; Government of Ontario; Canada Foundation for Innovation; Ryerson University","keywords":"Lysosome; Reactive oxygen species; Chemistry; Coalescence (physics); Oxygen; Cell biology; Biophysics; Biochemistry; Biology; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001820393,0.0003161634,0.0004790182,0.000137704,0.0001233952,0.000278379,0.0003281066,0.0003539927,0.0007809972],"category_scores_gemma":[0.0002193582,0.0001262164,0.0003565868,0.0001147242,0.0001695257,0.0002812315,0.0002424618,0.000671833,0.0001952252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002310844,"about_ca_system_score_gemma":0.0002063331,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006350496,"about_ca_topic_score_gemma":0.0006960939,"domain_scores_codex":[0.9997771,0.00002201767,0.00002833552,0.00004876056,0.00005625333,0.00006748012],"domain_scores_gemma":[0.9998436,0.00003008953,0.00004649841,0.00001794399,0.00002747048,0.00003445192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003799642,0.000066867,0.0001056449,0.00006894421,0.00001141393,0.00004868642,0.00002187037,0.00007483987,0.9975298,0.0000928244,0.00009623258,0.001502942],"study_design_scores_gemma":[0.00001142557,0.0001895617,0.0009569221,0.000003471519,0.000008836761,0.00004869906,0.00001010519,0.0006655485,0.9969558,0.0000232621,0.001122948,0.000003474881],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921216,0.002231009,0.003331476,0.0001328066,0.00007628129,0.00005187659,0.0003643078,0.0001594747,0.001531151],"genre_scores_gemma":[0.9956875,0.0006599604,0.001649147,0.00007377491,0.00001177919,0.00005518613,0.000444765,0.00002630029,0.001391591],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007809972,"threshold_uncertainty_score":0.00261271,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0255644367065177,"score_gpt":0.2138599013345283,"score_spread":0.1882954646280106,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}