{"id":"W3217106497","doi":"10.1093/neuonc/noab196.288","title":"DDRE-04. EFFECTIVENESS AND SAFETY OF OSIMERTINIB FOR PATIENTS WITH LEPTOMENINGEAL METASTASES FORM NON-SMALL CELL LUNG CANCER: A SYSTEMATIC REVIEW AND META-ANALYSIS","year":2021,"lang":"en","type":"review","venue":"Neuro-Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Osimertinib; Medicine; Common Terminology Criteria for Adverse Events; Internal medicine; Oncology; Lung cancer; Adverse effect; Meta-analysis; Hazard ratio; Epidermal growth factor receptor; Cancer; Confidence interval; Erlotinib","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.009406376,0.001881252,0.01402694,0.00605365,0.0004843191,0.002771374,0.001808576,0.002128643,0.005897093],"category_scores_gemma":[0.01794018,0.0009974056,0.03145225,0.006381311,0.0005784362,0.001640577,0.001240667,0.001646192,0.0005108769],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002452559,"about_ca_system_score_gemma":0.002808271,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004605669,"about_ca_topic_score_gemma":0.01176621,"domain_scores_codex":[0.993105,0.003106904,0.002046758,0.0007107103,0.0007982535,0.0002323413],"domain_scores_gemma":[0.9911963,0.005674546,0.001860495,0.0002410768,0.0008409016,0.0001866311],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.002260272,0.00003430124,0.00359929,0.5202418,0.4602399,0.0001102157,0.00006600586,0.0004145045,0.0002516865,0.000169753,0.0009728719,0.01163943],"study_design_scores_gemma":[0.001492548,0.0002799931,0.004488734,0.03276438,0.9575994,0.0001353693,0.00004792534,0.0002107684,0.0001232424,0.000232068,0.002597283,0.00002835529],"study_design_candidate":"meta_analysis","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007013389,0.9893106,0.0004640913,0.0003067587,0.000148787,0.0004800945,0.001666517,0.00003345318,0.0005762809],"genre_scores_gemma":[0.2589776,0.7315891,0.002371922,0.001637638,0.0003330429,0.001917043,0.002310817,0.00005009294,0.0008127434],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01402694,"threshold_uncertainty_score":0.04974627,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03459315506263771,"score_gpt":0.3857840444814286,"score_spread":0.3511908894187909,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}