{"id":"W3217143832","doi":"10.1093/neuonc/noab196.217","title":"CTIM-25. A RANDOMIZED PHASE 3 STUDY OF NIVOLUMAB OR PLACEBO COMBINED WITH RADIOTHERAPY PLUS TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WITH METHYLATED MGMT PROMOTER: CHECKMATE 548","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; Medicine; Nivolumab; Internal medicine; Placebo; Oncology; Radiation therapy; Phases of clinical research; Progression-free survival; Randomized controlled trial; Gastroenterology; Cancer; Clinical trial; Overall survival; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001349216,0.001226799,0.001841992,0.0004357423,0.0003611897,0.001048192,0.0009293969,0.001321593,0.004909001],"category_scores_gemma":[0.0009778556,0.0005969796,0.001451255,0.000360659,0.000901817,0.0006542619,0.0002919682,0.002226949,0.0008064836],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00105705,"about_ca_system_score_gemma":0.001721477,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001710397,"about_ca_topic_score_gemma":0.005492935,"domain_scores_codex":[0.999521,0.0002535754,0.00002487136,0.00007889423,0.00002889809,0.00009269773],"domain_scores_gemma":[0.9994412,0.0001056357,0.0001270195,0.00004062511,0.00003930823,0.0002462533],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9690982,0.008413169,0.000907161,0.0003645008,0.0007201859,0.0000384556,0.00003653285,0.000389368,0.005712223,0.00007989354,0.0009556339,0.01328465],"study_design_scores_gemma":[0.8849698,0.1099104,0.00227007,0.00002403351,0.0005367412,0.00002745466,0.00001944777,0.0004092635,0.0009416828,0.00009181084,0.0007833741,0.00001603109],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861843,0.003564395,0.000523939,0.0004809609,0.0005037793,0.004830144,0.001626451,0.0001567567,0.002129337],"genre_scores_gemma":[0.9909062,0.00114425,0.0008550531,0.0006654862,0.0001775205,0.003082795,0.001023077,0.00001804904,0.002127596],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004909001,"threshold_uncertainty_score":0.01642227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164306976075532,"score_gpt":0.2860758932714333,"score_spread":0.274432823510678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}