{"id":"W3217143832","doi":"10.1093/neuonc/noab196.217","title":"CTIM-25. A RANDOMIZED PHASE 3 STUDY OF NIVOLUMAB OR PLACEBO COMBINED WITH RADIOTHERAPY PLUS TEMOZOLOMIDE IN PATIENTS WITH NEWLY DIAGNOSED GLIOBLASTOMA WITH METHYLATED MGMT PROMOTER: CHECKMATE 548","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Temozolomide; Medicine; Nivolumab; Internal medicine; Placebo; Oncology; Radiation therapy; Phases of clinical research; Progression-free survival; Randomized controlled trial; Gastroenterology; Cancer; Clinical trial; Overall survival; Immunotherapy; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003693428,0.0005761853,0.002817906,0.0004173489,0.00008630102,0.00003040727,0.0001634094,0.0001987529,0.0001847939],"category_scores_gemma":[0.0003109665,0.0003330233,0.0001222454,0.00111408,0.0002739136,0.0001282068,0.00005827155,0.0004151474,0.000004772316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004961169,"about_ca_system_score_gemma":0.001002381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002751198,"about_ca_topic_score_gemma":0.002618781,"domain_scores_codex":[0.99586,0.001194198,0.0008901058,0.0008844256,0.0005924295,0.0005788803],"domain_scores_gemma":[0.9964979,0.001411051,0.000632552,0.0007053239,0.0004760383,0.0002770882],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8632003,0.03862647,0.06489868,0.00009911892,0.002151409,0.0137439,0.003647549,0.0002843782,0.008301284,0.000005624192,0.0001505549,0.004890702],"study_design_scores_gemma":[0.8443558,0.1247658,0.0106693,0.0002096257,0.001135532,0.0002314647,0.0007074685,0.0007223295,0.01662267,0.00000247178,0.0002632262,0.0003143309],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9899723,0.0001251339,0.00004063914,0.0007574298,0.0001182051,0.008734738,0.00001956128,0.0001013939,0.0001306221],"genre_scores_gemma":[0.9964803,0.00006025498,0.00131296,0.0004543247,0.00003026456,0.001449937,0.00005867162,0.0001179181,0.00003532328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08613934,"threshold_uncertainty_score":0.9999122,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01164306976075532,"score_gpt":0.2860758932714333,"score_spread":0.274432823510678,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}