{"id":"W3217164139","doi":"","title":"Shared Genetic Pathways Contribute to Risk of Hypertrophic and Dilated Cardiomyopathies With Opposite Directions of Effect","year":2020,"lang":"en","type":"article","venue":"Utrecht University Repository (Utrecht University)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; Daiichi Sankyo Europe; National Cancer Institute; NIH Office of the Director; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Servier; Medical Research Council; National Institutes of Health; Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; Horizon 2020 Framework Programme; Esperion Therapeutics; Mason Medical Research Trust; European Research Area Network on Cardiovascular Diseases; Canadian Institutes of Health Research; Ipsen; Fondation Institut de Cardiologie de Montréal; UK Dementia Research Institute; Université de Montréal; Netherlands Heart Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Universitair Medisch Centrum Groningen; ZonMw; Fondation Leducq; European Society of Cardiology; GlaxoSmithKline; BHF Centre of Research Excellence, Oxford; Wellcome Trust; Imperial College Healthcare NHS Trust; Japan Society for the Promotion of Science; Heart Rhythm Society; Imperial College London; National Institute for Health and Care Research; Stichting Volksbond Rotterdam; Amsterdam University Medical Centers; Conny-Maeva Charitable Foundation; Novo Nordisk; MyoKardia; British Heart Foundation; Pfizer; Università degli Studi di Firenze; Cytokinetics; Sanofi; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Klaus Tschira Stiftung; European Commission; AstraZeneca; Amarin Corporation; Biogen; Institut de Cardiologie de Montréal; Heart and Stroke Foundation of Canada; National Human Genome Research Institute; Celgene; UK Research and Innovation; Bristol-Myers Squibb","keywords":"Medicine; Dilated cardiomyopathy; Hypertrophic cardiomyopathy; Cardiology; Internal medicine; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001347417,0.0004642367,0.0004460448,0.001152939,0.0003664351,0.0006643818,0.0002949096,0.0006055312,0.002320079],"category_scores_gemma":[0.004170441,0.0002145571,0.0006373689,0.0009289175,0.0007381084,0.0002435129,0.0008280965,0.0005087844,0.0001432892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001825261,"about_ca_system_score_gemma":0.0002929301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001656758,"about_ca_topic_score_gemma":0.002192335,"domain_scores_codex":[0.9982546,0.0009001399,0.0001162259,0.0004069593,0.0001640485,0.0001579711],"domain_scores_gemma":[0.9973788,0.001286014,0.0007317978,0.0002586083,0.00009237995,0.0002523412],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0008420926,0.00003815697,0.9779474,0.00003586944,0.0006457873,0.001227146,0.0003454017,0.0002560191,0.01084012,0.0006947218,0.0001251501,0.007002064],"study_design_scores_gemma":[0.000042893,0.0001147271,0.9956787,0.00002332321,0.0003169533,0.001572345,0.0001582799,0.0004453908,0.000548019,0.0009263405,0.0001620104,0.00001089523],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982392,0.0005173442,0.0004401397,0.0001497875,0.000007569981,0.000004962797,0.0001365675,0.00000581643,0.0004986235],"genre_scores_gemma":[0.9990445,0.0001394573,0.0004739275,0.00004964923,0.000008162586,0.000004947305,0.0001192226,0.000004066228,0.0001559614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002320079,"threshold_uncertainty_score":0.007761419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007597661284683629,"score_gpt":0.1645369305461778,"score_spread":0.1569392692614942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}