{"id":"W3217164139","doi":"","title":"Shared Genetic Pathways Contribute to Risk of Hypertrophic and Dilated Cardiomyopathies With Opposite Directions of Effect","year":2020,"lang":"en","type":"article","venue":"Utrecht University Repository (Utrecht University)","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; Daiichi Sankyo Europe; National Cancer Institute; NIH Office of the Director; National Institute on Drug Abuse; National Institute of Mental Health; National Heart, Lung, and Blood Institute; Servier; Medical Research Council; National Institutes of Health; Amsterdam Cardiovascular Sciences, Amsterdam University Medical Centers; Horizon 2020 Framework Programme; Esperion Therapeutics; Mason Medical Research Trust; European Research Area Network on Cardiovascular Diseases; Canadian Institutes of Health Research; Ipsen; Fondation Institut de Cardiologie de Montréal; UK Dementia Research Institute; Université de Montréal; Netherlands Heart Institute; Deutsches Zentrum für Herz-Kreislaufforschung; Universitair Medisch Centrum Groningen; ZonMw; Fondation Leducq; European Society of Cardiology; GlaxoSmithKline; BHF Centre of Research Excellence, Oxford; Wellcome Trust; Imperial College Healthcare NHS Trust; Japan Society for the Promotion of Science; Heart Rhythm Society; Imperial College London; National Institute for Health and Care Research; Stichting Volksbond Rotterdam; Amsterdam University Medical Centers; Conny-Maeva Charitable Foundation; Novo Nordisk; MyoKardia; British Heart Foundation; Pfizer; Università degli Studi di Firenze; Cytokinetics; Sanofi; NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research; Klaus Tschira Stiftung; European Commission; AstraZeneca; Amarin Corporation; Biogen; Institut de Cardiologie de Montréal; Heart and Stroke Foundation of Canada; National Human Genome Research Institute; Celgene; UK Research and Innovation; Bristol-Myers Squibb","keywords":"Medicine; Dilated cardiomyopathy; Hypertrophic cardiomyopathy; Cardiology; Internal medicine; Heart failure","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001305153,0.0002994868,0.0009564145,0.0004533718,0.0003488057,0.00001095482,0.0001857765,0.0001708543,0.000006506424],"category_scores_gemma":[0.00009455135,0.0002946636,0.0002877658,0.001317462,0.0003387194,0.0001482231,0.0002663725,0.0002841634,0.000002642958],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000173283,"about_ca_system_score_gemma":0.0001565772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005678424,"about_ca_topic_score_gemma":0.00002604883,"domain_scores_codex":[0.9983261,0.0003160655,0.0002215748,0.0005470389,0.0003199312,0.0002693113],"domain_scores_gemma":[0.9983444,0.0002351362,0.0002433477,0.0003754439,0.0003916287,0.0004100072],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0174798,0.0004369072,0.8000783,0.00130517,0.006637578,0.008589871,0.006760817,0.0004977735,0.1456358,0.0004568189,0.001321865,0.0107993],"study_design_scores_gemma":[0.02141933,0.01390071,0.7089157,0.001998446,0.01853386,0.001181635,0.01014681,0.0004180821,0.1381818,0.00001211994,0.08359603,0.001695529],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886807,0.0006849499,0.0007280909,0.0002533391,0.0001126394,0.0006777557,0.00023081,0.0001544345,0.008477327],"genre_scores_gemma":[0.9972089,0.0006724259,0.0008375718,0.00003225274,0.00005950953,5.117433e-7,0.00001386747,0.00002081624,0.001154155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09116265,"threshold_uncertainty_score":0.9999505,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007597661284683629,"score_gpt":0.1645369305461778,"score_spread":0.1569392692614942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}