{"id":"W3217205918","doi":"10.1182/blood-2021-146175","title":"Dose Modification Dynamics of Ponatinib in Patients with Chronic-Phase Chronic Myeloid Leukemia (CP-CML) from the PACE and Optic Trials","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Chronic Myeloid Leukemia Treatments","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ponatinib; Medicine; Adverse effect; Internal medicine; Dosing; Clinical trial; Myeloid leukemia; Oncology; Nilotinib; Imatinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006878779,0.0003556978,0.0009022438,0.0003166817,0.0003105791,0.0009702903,0.0005726775,0.0006204951,0.002058369],"category_scores_gemma":[0.008848969,0.0002409105,0.001303591,0.0005859678,0.0003600087,0.001159253,0.0006938266,0.001425616,0.0002648783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001063279,"about_ca_system_score_gemma":0.001080092,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006016857,"about_ca_topic_score_gemma":0.001196119,"domain_scores_codex":[0.9959762,0.001626392,0.0004373806,0.0008167286,0.0008758953,0.0002674393],"domain_scores_gemma":[0.995741,0.001486539,0.001616098,0.0004171113,0.0003488607,0.0003904138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.494277,0.004083659,0.2070795,0.001270497,0.005282904,0.000203417,0.0004438,0.007376682,0.009623572,0.001810016,0.01598905,0.25256],"study_design_scores_gemma":[0.1360445,0.1644213,0.6101466,0.0002732852,0.005016715,0.001495421,0.0003035563,0.009376779,0.008975456,0.003049463,0.06069913,0.0001979083],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842678,0.00382594,0.0008920273,0.000500767,0.0000684544,0.0008534795,0.003881159,0.00003442514,0.005676006],"genre_scores_gemma":[0.9904051,0.0007474925,0.0008534206,0.0006552289,0.0001163894,0.0008544704,0.005624589,0.00001445153,0.0007286746],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006878779,"threshold_uncertainty_score":0.03637892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02121465185745139,"score_gpt":0.2855024464408717,"score_spread":0.2642877945834203,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}