{"id":"W3217210659","doi":"10.1093/neuonc/noab196.026","title":"EPCO-27. SINGLE-CELL ANALYSIS OF ETMR PATIENT SAMPLES LINKS TRANSCRIPTIONAL PHENOTYPES TO GENETIC DRIVER ALTERATIONS AND INFORMS NOVEL THERAPEUTIC STRATEGIES","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre","funders":"","keywords":"Biology; SOX2; Embryonic stem cell; Stem cell; Phenotype; Neural stem cell; microRNA; Population; Progenitor cell; Cell; Gene silencing; KLF4; Cancer research; Genetics; Cell biology; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003864891,0.0001967435,0.000280975,0.0004854889,0.0002612279,0.0003643451,0.000284873,0.0003441079,0.004607232],"category_scores_gemma":[0.0003495919,0.0001029563,0.000156942,0.0003487058,0.0002049654,0.0001238744,0.0002074467,0.0004125035,0.00169075],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002553974,"about_ca_system_score_gemma":0.0001972792,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041541,"about_ca_topic_score_gemma":0.001893553,"domain_scores_codex":[0.9997721,0.00001987722,0.0000263651,0.00007520444,0.00006774602,0.0000387513],"domain_scores_gemma":[0.9997571,0.00005169638,0.00002917616,0.00004022131,0.00006775837,0.00005397817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005674433,0.00007931426,0.02303754,0.00009845933,0.00003031487,0.001429887,0.00007596254,0.0002630763,0.9586609,0.0002164659,0.001782881,0.01375779],"study_design_scores_gemma":[0.00006106207,0.0005643978,0.2328979,0.00003744315,0.0000706492,0.009784781,0.0001819003,0.003668289,0.7267904,0.0002624991,0.02566307,0.00001758661],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9695708,0.001588733,0.009777101,0.0003819015,0.00005870981,0.0002171185,0.01099518,0.0004223105,0.006988172],"genre_scores_gemma":[0.9665259,0.000708746,0.01051754,0.0002410035,0.00002039977,0.0002555867,0.01608284,0.0001544754,0.005493525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004607232,"threshold_uncertainty_score":0.01541275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02133346371307063,"score_gpt":0.2644507298644257,"score_spread":0.2431172661513551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}