{"id":"W3217243785","doi":"10.1182/blood-2021-148909","title":"The Benefits Trial of PB-04 to Evaluate Safety, PK, and Preliminary Efficacy in Inducing Fetal Globin Expression in Beta Thalassemia Intermedia and Sickle Cell Disease","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"Fetal hemoglobin; Thalassemia; Globin; Hemoglobinopathy; Medicine; Sickle cell anemia; Fetus; Pharmacology; Immunology; Biology; Internal medicine; Disease; Hemoglobin; Hemolytic anemia; Genetics; Pregnancy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006257799,0.0006355891,0.0008799529,0.0004130343,0.000257014,0.0007307896,0.0004507135,0.0008778672,0.004026796],"category_scores_gemma":[0.000444403,0.0002153899,0.0005947225,0.0002341157,0.0007658219,0.0004810769,0.0002363714,0.001991276,0.0005876909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005662263,"about_ca_system_score_gemma":0.0007795139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000602299,"about_ca_topic_score_gemma":0.0008979535,"domain_scores_codex":[0.9997839,0.0000848435,0.00001306228,0.00004168756,0.00002291748,0.00005350222],"domain_scores_gemma":[0.9996251,0.00006913918,0.00004921783,0.00003942612,0.0000272958,0.0001898386],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5622607,0.09037951,0.004424377,0.0006984606,0.0007958506,0.0006400043,0.0002290092,0.002023837,0.1686051,0.001462973,0.004033136,0.164447],"study_design_scores_gemma":[0.1067089,0.8337061,0.006598322,0.00005914048,0.0004355548,0.0004494717,0.00008889899,0.001592849,0.04265573,0.0005498672,0.007124543,0.00003055192],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938984,0.002692315,0.0003546209,0.0003365367,0.0001109704,0.0002849018,0.0003976645,0.00007108545,0.001853571],"genre_scores_gemma":[0.9926157,0.001045949,0.0005298447,0.0003317426,0.0000823873,0.0003688772,0.0006939225,0.00001291999,0.004318742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004026796,"threshold_uncertainty_score":0.01347101,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01042157170967727,"score_gpt":0.2556412724445561,"score_spread":0.2452197007348789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}