{"id":"W3217256203","doi":"10.1101/2021.12.01.470829","title":"Ikaros family proteins regulate developmental windows in the mouse retina through convergent and divergent transcriptional programs","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"Canadian Institutes of Health Research; Institut de Recherche Clinique De Montréal","keywords":"Biology; HES1; Muller glia; Cell biology; Cell fate determination; Transcription factor; Progenitor cell; Genetics; Progenitor; Zinc finger; Neural development; Gene; Downregulation and upregulation; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004816927,0.0005183409,0.0003542522,0.00006638934,0.0001758955,0.0002152284,0.0004660765,0.0004564575,0.00002024768],"category_scores_gemma":[0.00005551257,0.0004626309,0.0001465149,0.0002328109,0.0001971918,0.00001928776,0.000438829,0.0004243267,0.000006377596],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008906434,"about_ca_system_score_gemma":0.0006477845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008458007,"about_ca_topic_score_gemma":0.00002780844,"domain_scores_codex":[0.9973327,0.0002000175,0.0005085256,0.001018718,0.0004411015,0.0004989187],"domain_scores_gemma":[0.9989605,0.000007476732,0.0001902651,0.0005236086,0.0001990355,0.0001191019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001122362,0.0002701935,0.03328302,0.0002300938,0.0001518459,0.0000479592,0.0001457707,0.00001779574,0.9652536,0.0001553481,0.0003249885,0.000007160882],"study_design_scores_gemma":[0.001771359,0.0001916816,0.5334963,0.0003558469,0.00008616225,3.61435e-7,0.0002740711,0.00003946927,0.4290965,0.000006580833,0.03320899,0.001472796],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944125,0.002796449,0.00052062,0.0003021476,0.0002959862,0.001549484,0.00005055089,0.00004106887,0.00003114978],"genre_scores_gemma":[0.9904211,0.002007642,0.006230874,0.0004443358,0.0001250285,0.0006590078,0.00002193526,0.00006414334,0.00002595185],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5361571,"threshold_uncertainty_score":0.9997826,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01615387695653818,"score_gpt":0.2096851179757579,"score_spread":0.1935312410192197,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}