{"id":"W3217270573","doi":"10.1101/2021.11.29.470412","title":"The VINE complex is a VPS9-domain GEF-containing SNX-BAR coat involved in endosomal sorting","year":2021,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Children's Hospital; University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Weizmann Institute of Science; Concordia University; Université Laval; University of Alberta; Canadian Institutes of Health Research","keywords":"Retromer; Sorting nexin; Endosome; Cell biology; Biology; Transport protein; Vesicular Transport Proteins; Protein targeting; Vacuolar protein sorting; Membrane protein; Genetics; Membrane","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009854636,0.0003471055,0.0001705905,0.0003571715,0.0003033888,0.0005961842,0.0001740511,0.0003347819,0.002584808],"category_scores_gemma":[0.0001271783,0.0001603842,0.0001810863,0.0001875297,0.0002284803,0.0001895296,0.0003401622,0.0002441399,0.00111777],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004661377,"about_ca_system_score_gemma":0.0001425877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006273378,"about_ca_topic_score_gemma":0.0005941545,"domain_scores_codex":[0.9999073,0.000009549878,0.000005384326,0.00002570429,0.00003720861,0.00001497109],"domain_scores_gemma":[0.999959,0.000004599297,0.00001069621,0.000005682928,0.000004319774,0.00001574596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008484373,0.00002128057,0.001176028,0.00005344769,0.00002926177,0.0002342327,0.00001489083,0.0004201774,0.9913774,0.003025306,0.0006441153,0.00291899],"study_design_scores_gemma":[0.00001732426,0.00003515121,0.009850863,0.000007892359,0.00001239832,0.0009696906,0.0000272894,0.007793328,0.9577936,0.0006911015,0.02279236,0.000008939488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9603785,0.0016232,0.02596787,0.0003446776,0.0001990339,0.00003436714,0.001359443,0.0007797942,0.00931326],"genre_scores_gemma":[0.9726223,0.0004246108,0.006650978,0.00002848103,0.00001982843,0.00000813076,0.003105182,0.0001667198,0.01697378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002584808,"threshold_uncertainty_score":0.008647084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01571192955206469,"score_gpt":0.2184403025638886,"score_spread":0.2027283730118239,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}