{"id":"W3217292243","doi":"10.1016/j.cjca.2021.11.012","title":"The Quest for a Biomarker of Premature Biological Aging","year":2021,"lang":"en","type":"letter","venue":"Canadian Journal of Cardiology","topic":"Telomeres, Telomerase, and Senescence","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Montreal Heart Institute","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Biomarker; Disease; Biological age; Premature aging; Cause of death; Psychological intervention; Internal medicine; Gerontology; Physiology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005329687,0.000708288,0.002535056,0.00128575,0.003342615,0.003219003,0.00151546,0.03980442,0.003253136],"category_scores_gemma":[0.03144348,0.0004785711,0.0008993265,0.0008879615,0.003603877,0.003755274,0.00104208,0.0401294,0.00237984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.004113981,"about_ca_system_score_gemma":0.005618834,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0112806,"about_ca_topic_score_gemma":0.01730806,"domain_scores_codex":[0.9965663,0.00127887,0.0004595208,0.0003555356,0.001071856,0.0002679916],"domain_scores_gemma":[0.9801787,0.01214636,0.000814814,0.0004723947,0.004101718,0.002286059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.000167212,0.0001075734,0.004483676,0.0001531142,0.00004450075,0.003822406,0.0002750604,0.00008101891,0.0005235563,0.006799725,0.9390261,0.04451616],"study_design_scores_gemma":[0.0004634881,0.0002415402,0.005297599,0.001087848,0.0001292144,0.008474275,0.001431943,0.001114829,0.0005530597,0.03964074,0.9414179,0.0001476117],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003592681,0.003740325,0.0001092408,0.9833261,0.01158737,0.000006110861,0.00003104754,0.00001157951,0.0008289197],"genre_scores_gemma":[0.007279458,0.006147423,0.0007569356,0.8466847,0.1358603,0.00005217486,0.00004503729,0.00001824401,0.003155714],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03980442,"threshold_uncertainty_score":0.02984923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04359826149678226,"score_gpt":0.2746148450831962,"score_spread":0.231016583586414,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}