{"id":"W3217307305","doi":"10.3390/cancers13235906","title":"Mutation Profile Variability in the Primary Tumor and Multiple Pulmonary Metastases of Clear Cell Renal Cell Carcinoma. A Review of the Literature and Analysis of Four Metastatic Cases","year":2021,"lang":"en","type":"review","venue":"Cancers","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Renal cell carcinoma; Clear cell renal cell carcinoma; Primary tumor; Metastasis; Oncology; Mutation; Immunohistochemistry; Internal medicine; Cell; Pathology; Genetic heterogeneity; Cancer; Gene; Phenotype; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005886671,0.0004066983,0.001128745,0.003338709,0.0001603518,0.000500578,0.0005915262,0.0005565287,0.0009874211],"category_scores_gemma":[0.001153848,0.0001871969,0.0005111602,0.002475963,0.0002770392,0.0006950529,0.0002781537,0.0003295395,0.0003544688],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003256956,"about_ca_system_score_gemma":0.000857803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001321412,"about_ca_topic_score_gemma":0.002374262,"domain_scores_codex":[0.9996759,0.0000539265,0.0001038067,0.00005979027,0.00008731892,0.00001923722],"domain_scores_gemma":[0.9994837,0.0002886002,0.0001085901,0.00001256977,0.00008626807,0.00002033649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"case_report","study_design_scores_codex":[0.000162427,0.00003550549,0.004902015,0.04480662,0.0004453575,0.003116561,0.0002140977,0.0001987982,0.00228351,0.000627139,0.009618296,0.9335897],"study_design_scores_gemma":[0.0000618116,0.0006270292,0.07687892,0.03595308,0.004234375,0.1153581,0.0009049255,0.0004162897,0.003433994,0.001570075,0.7604372,0.0001241228],"study_design_candidate":"case_report","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001078283,0.9982114,0.00007891704,0.00008646183,0.00005661368,0.000005258796,0.00003926533,0.000003414974,0.0004405014],"genre_scores_gemma":[0.009894339,0.9891685,0.0003002209,0.0001820548,0.0001005669,0.000008420151,0.0001071545,0.000002234267,0.0002365074],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003338709,"threshold_uncertainty_score":0.00330323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03840666203221902,"score_gpt":0.2961032580896944,"score_spread":0.2576965960574754,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}