{"id":"W3217310573","doi":"10.1016/j.vaccine.2021.11.049","title":"Recombinant Bacillus subtilis flagellin Hag is a potent immunostimulant with reduced proinflammatory properties compared to Salmonella enterica serovar Typhimurium FljB","year":2021,"lang":"en","type":"article","venue":"Vaccine","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"PROTEO; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; International Development Research Centre; Université du Québec à Montréal","keywords":"Flagellin; TLR5; Proinflammatory cytokine; Salmonella enterica; Microbiology; Biology; Salmonella; Bacillus subtilis; Immune system; Immunology; Bacteria; Innate immune system; Toll-like receptor; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001899681,0.0002778105,0.0002868763,0.0002506328,0.0001194018,0.0002714824,0.0001770607,0.0003313949,0.001243448],"category_scores_gemma":[0.0001435071,0.0001322927,0.0002041788,0.0001253047,0.0002190697,0.0002083299,0.0001829129,0.0005894107,0.000266472],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002007525,"about_ca_system_score_gemma":0.0002857017,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007144361,"about_ca_topic_score_gemma":0.0007938675,"domain_scores_codex":[0.9998674,0.00002136035,0.000008410926,0.00001622965,0.00004135086,0.00004514601],"domain_scores_gemma":[0.9998811,0.0000193997,0.00002877516,0.000009200444,0.00001464098,0.00004688216],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009670847,0.00007204612,0.0001029642,0.00002726692,0.000004207295,0.00002391224,0.000005373448,0.00005655466,0.9978224,0.00001951562,0.00002925113,0.0008694454],"study_design_scores_gemma":[0.00006067148,0.001662959,0.00263357,0.000004208187,0.00001532313,0.0001811673,0.00002384291,0.0003147665,0.9941412,0.00002200697,0.0009348736,0.000005475002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980999,0.0006238834,0.0005848458,0.00006262996,0.00003217598,0.00001047125,0.000147928,0.00003580109,0.0004023907],"genre_scores_gemma":[0.9965919,0.0002824769,0.0007812933,0.00003897435,0.00001396792,0.000009480473,0.0006274887,0.00001072002,0.001643604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001243448,"threshold_uncertainty_score":0.004159749,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01425870435637074,"score_gpt":0.2095105059872327,"score_spread":0.1952518016308619,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}