{"id":"W3217321524","doi":"10.1093/neuonc/noab196.246","title":"CTNI-21. PHASE 2 STUDY OF VAL-083 AND RADIOTHERAPY IN NEWLY DIAGNOSED MGMT-UNMETHYLATED GBM","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Temozolomide; Medicine; Methyltransferase; Radiation therapy; O-6-methylguanine-DNA methyltransferase; In vivo; Internal medicine; Phases of clinical research; Oncology; Stage (stratigraphy); Gastroenterology; Cancer research; Chemotherapy; Biology; DNA; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001541386,0.001929152,0.001908132,0.0006504206,0.0005618026,0.001006694,0.001727419,0.001434055,0.002478594],"category_scores_gemma":[0.0006928606,0.001005544,0.001052868,0.0005705078,0.001075141,0.0006352564,0.0005088846,0.003844779,0.0009419004],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001284167,"about_ca_system_score_gemma":0.002966481,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003087285,"about_ca_topic_score_gemma":0.006953357,"domain_scores_codex":[0.9995517,0.0002095858,0.00002024545,0.00007360875,0.00005621662,0.0000886161],"domain_scores_gemma":[0.9993825,0.0000443738,0.0000952413,0.00006661227,0.00004853398,0.0003628189],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.4439605,0.2120252,0.008282368,0.001012992,0.001422652,0.0007672875,0.0006773685,0.007515522,0.2211342,0.0006437971,0.006887445,0.09567066],"study_design_scores_gemma":[0.260052,0.6934506,0.01232836,0.00004066916,0.0004458915,0.0007640332,0.00008398724,0.002286068,0.02480463,0.0002367529,0.005449063,0.00005801852],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906356,0.001550583,0.0005394784,0.0003308324,0.0001528111,0.003637464,0.001245705,0.0001272071,0.001780297],"genre_scores_gemma":[0.9787396,0.002108595,0.003271984,0.0007736691,0.0001712035,0.004750205,0.004451748,0.00007832029,0.005654606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003087285,"threshold_uncertainty_score":0.009317338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02563256671107268,"score_gpt":0.3462562865145244,"score_spread":0.3206237198034518,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}