{"id":"W3217351888","doi":"10.1016/j.antiviral.2021.105211","title":"Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein","year":2021,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"cccDNA; HBsAg; Virology; HBeAg; In vitro; Hepatitis B virus; In vivo; Viral replication; Biology; Molecular biology; Hepatitis B; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006410506,0.0007587673,0.000429979,0.000457974,0.0002871628,0.0004444161,0.0005458096,0.000525889,0.004038085],"category_scores_gemma":[0.0004003499,0.0002801768,0.0004219414,0.0002028405,0.0003146635,0.0004081147,0.0001147259,0.001187867,0.0008366781],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003877592,"about_ca_system_score_gemma":0.0009238463,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001365176,"about_ca_topic_score_gemma":0.002033453,"domain_scores_codex":[0.9998298,0.00005294167,0.000009591943,0.0000175895,0.00002848796,0.00006165155],"domain_scores_gemma":[0.9997658,0.00004321122,0.00004336226,0.00002208674,0.00004001887,0.00008550919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01407139,0.01390258,0.0007566677,0.0005034786,0.0001648122,0.0002999303,0.0001401881,0.002565569,0.928458,0.0009028721,0.002328743,0.03590582],"study_design_scores_gemma":[0.007397634,0.2169324,0.006048155,0.00006570891,0.0004232799,0.0008512303,0.0001064449,0.003658337,0.7464325,0.000361028,0.01768389,0.00003944158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9772815,0.005092746,0.005514759,0.0005383345,0.0001462413,0.001464435,0.001893641,0.00020512,0.007863262],"genre_scores_gemma":[0.9836245,0.004329396,0.002906939,0.0002341484,0.00007153978,0.0003851902,0.002622572,0.00003922353,0.005786511],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004038085,"threshold_uncertainty_score":0.0135088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1841789091006543,"score_gpt":0.4626211320481227,"score_spread":0.2784422229474683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}