{"id":"W3217351888","doi":"10.1016/j.antiviral.2021.105211","title":"Preclinical characterization of AB-506, an inhibitor of HBV replication targeting the viral core protein","year":2021,"lang":"en","type":"article","venue":"Antiviral Research","topic":"Hepatitis B Virus Studies","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":false,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"cccDNA; HBsAg; Virology; HBeAg; In vitro; Hepatitis B virus; In vivo; Viral replication; Biology; Molecular biology; Hepatitis B; Virus; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002433781,0.00008405366,0.0002859795,0.00008215481,0.0001383168,0.0000144458,0.0001341997,0.00009203457,0.00002597149],"category_scores_gemma":[0.005348546,0.00006129152,0.00007166625,0.0004804852,0.0003693392,0.0001493903,0.0001948283,0.0003934167,0.0000189943],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000349468,"about_ca_system_score_gemma":0.0002879128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002790841,"about_ca_topic_score_gemma":0.00008488622,"domain_scores_codex":[0.9976806,0.0004588393,0.0004995089,0.0003410018,0.0007544512,0.0002655789],"domain_scores_gemma":[0.9977515,0.0002313831,0.000147278,0.00063185,0.001198959,0.00003907096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000162392,0.0002418375,0.09710076,0.0001479441,0.00002594507,0.000009377572,0.000428855,2.742233e-8,0.8900319,0.0006532584,0.0002168979,0.01098081],"study_design_scores_gemma":[0.0002992786,0.0005203666,0.2520924,0.000208176,0.00001141397,0.000001598842,0.0001192595,0.0002274958,0.745576,0.0001350028,0.0007626002,0.00004635002],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964592,0.0001051002,0.00004572126,0.001596773,0.00004105756,0.0007484815,0.00002990091,0.00001787758,0.0009558584],"genre_scores_gemma":[0.9980538,0.0002010044,0.0003454913,0.00004353431,0.000249343,0.00006723613,0.0001420908,0.00001866499,0.0008787956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1549917,"threshold_uncertainty_score":0.6403096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1841789091006543,"score_gpt":0.4626211320481227,"score_spread":0.2784422229474683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}