{"id":"W3217358129","doi":"10.7554/elife.64695.sa1","title":"Decision letter: A novel, ataxic mouse model of ataxia telangiectasia caused by a clinically relevant nonsense mutation","year":2021,"lang":"en","type":"peer-review","venue":"","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Ataxia-telangiectasia; Ataxia; Null allele; Nonsense mutation; Mutation; Neuroscience; Cerebellar ataxia; Atrophy; Biology; Missense mutation; Genetics; Phenotype; Gene; DNA damage; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00256459,0.0005843605,0.0004948697,0.0006503056,0.001004312,0.001393745,0.001410655,0.004707651,0.05498667],"category_scores_gemma":[0.006488675,0.0004410269,0.0007505189,0.0002442808,0.0005426601,0.001001636,0.0007061979,0.002636711,0.02047142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000819895,"about_ca_system_score_gemma":0.001557474,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004877551,"about_ca_topic_score_gemma":0.001396843,"domain_scores_codex":[0.9982758,0.0003674617,0.0002584095,0.0002018315,0.0007147841,0.0001818669],"domain_scores_gemma":[0.9949363,0.001226327,0.0004956297,0.0004836178,0.001700718,0.001157302],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007149361,0.0002152054,0.0006813191,0.000183603,0.00001940946,0.001506339,0.00003396084,0.00007649238,0.005768497,0.002359953,0.9573302,0.03111],"study_design_scores_gemma":[0.0003695971,0.0003256164,0.001465752,0.0001889401,0.00003897308,0.003089135,0.00006269189,0.0008566994,0.01023106,0.002718066,0.980608,0.00004551951],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.05045068,0.003317817,0.03329124,0.4360948,0.2978378,0.004796758,0.0258112,0.008013829,0.1403859],"genre_scores_gemma":[0.144307,0.00531637,0.06149293,0.2078694,0.09238355,0.004137794,0.01940833,0.002317732,0.4627669],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.05498667,"threshold_uncertainty_score":0.1839488,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02696884677549517,"score_gpt":0.3072821782414061,"score_spread":0.2803133314659109,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}