{"id":"W3217378019","doi":"10.1093/neuonc/noab196.020","title":"EPCO-21. CORE REGULATORY CIRCUIT TRANSCRIPTION FACTORS DRIVE EXPRESSION FROM HIGH LEVEL AMPLICONS IN PEDIATRIC HIGH-GRADE GLIOMAS","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Circular RNAs in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Oncogene; Enhancer; Amplicon; Biology; Transcription factor; Cancer research; Oncogene Proteins; Genetics; Gene; Regulation of gene expression; Cell cycle; Polymerase chain reaction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001994583,0.0002519812,0.000325749,0.0003843465,0.0002751742,0.0005099961,0.0002630654,0.0002641759,0.004641258],"category_scores_gemma":[0.0003423308,0.0002151836,0.0002828635,0.0003992837,0.0002601356,0.0002222669,0.0004110554,0.0004338577,0.001388337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005616433,"about_ca_system_score_gemma":0.0004925151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002121042,"about_ca_topic_score_gemma":0.004236286,"domain_scores_codex":[0.9997125,0.00001611834,0.00001396113,0.0001050583,0.00008349404,0.00006876179],"domain_scores_gemma":[0.9996322,0.00005984219,0.0001052748,0.00003655545,0.00008079864,0.00008528643],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004747002,0.0000475866,0.02253004,0.0002455593,0.00002422333,0.0001455896,0.00008561937,0.0004757658,0.9603962,0.0003134175,0.001052831,0.01420837],"study_design_scores_gemma":[0.00004530189,0.0003236418,0.2924918,0.0000483319,0.00007264617,0.00104551,0.0002158003,0.003647424,0.6856835,0.0003630265,0.0160423,0.00002068375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803883,0.001605464,0.005565969,0.0001209133,0.00003803591,0.00005506837,0.008130909,0.0004142141,0.003681157],"genre_scores_gemma":[0.9799968,0.0005861666,0.005254567,0.000171938,0.00001181506,0.00008681874,0.009726624,0.0001799144,0.003985446],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004641258,"threshold_uncertainty_score":0.01552659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04037904642475229,"score_gpt":0.2760099696800771,"score_spread":0.2356309232553248,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}