{"id":"W3217383311","doi":"10.1038/s41586-021-04144-4","title":"FAM72A antagonizes UNG2 to promote mutagenic repair during antibody maturation","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":false,"ca_institutions":"Sunnybrook Health Science Centre; Sinai Health System; Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Université de Montréal; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute","keywords":"Somatic hypermutation; Cytidine deaminase; DNA glycosylase; Uracil-DNA glycosylase; Immunoglobulin class switching; DNA repair; Mutagenesis; DNA mismatch repair; Base excision repair; Activation-induced (cytidine) deaminase; Mutation; Chemistry; Biology; Cell biology; Cell cycle checkpoint; DNA; Cell cycle; Genetics; Gene; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002848738,0.0004449831,0.0003836484,0.0003294296,0.0003012915,0.0005175149,0.00068126,0.0006696134,0.004766791],"category_scores_gemma":[0.000388559,0.0002413158,0.0003176166,0.000176539,0.0003515214,0.0003323758,0.0003578842,0.0009172754,0.001063436],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007087881,"about_ca_system_score_gemma":0.0003321315,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493156,"about_ca_topic_score_gemma":0.002565067,"domain_scores_codex":[0.9997557,0.00003173775,0.00001569343,0.00006293063,0.00005344844,0.00008052651],"domain_scores_gemma":[0.999806,0.00004318642,0.00004839542,0.00002826983,0.00001992853,0.00005432548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007260899,0.00003749597,0.0002016153,0.0000436361,0.00001301655,0.0001326263,0.000007717744,0.0001528814,0.9944512,0.0003861267,0.0003237258,0.003523719],"study_design_scores_gemma":[0.000046925,0.0001557953,0.001594797,0.000005169675,0.000007644897,0.0002266399,0.00001205663,0.000900637,0.9929583,0.00007594615,0.004010263,0.000005827379],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9803773,0.004999725,0.005125382,0.0009415026,0.0002387321,0.00005792721,0.0009437874,0.0007286135,0.006587027],"genre_scores_gemma":[0.9943104,0.0005291901,0.00155695,0.0001360651,0.00001717889,0.0000267078,0.0004502517,0.00007312981,0.002900101],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004766791,"threshold_uncertainty_score":0.01594651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003808065021181618,"score_gpt":0.2609129150908446,"score_spread":0.2571048500696629,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}