{"id":"W3217446559","doi":"10.1152/ajpcell.00130.2021","title":"Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; McMaster University","keywords":"Fragile X syndrome; Oxidative stress; Bioenergetics; Biology; Mitochondrion; Astrocyte; FMR1; Reactive oxygen species; Microglia; Neuroscience; Cell biology; Endocrinology; Internal medicine; Central nervous system; Genetics; Immunology; Medicine; Gene; Fragile x; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000349244,0.0002001503,0.0004867238,0.00009089152,0.00003912687,0.000004875904,0.0001655653,0.0001001289,0.00002268708],"category_scores_gemma":[0.00006682263,0.0001784897,0.0001342038,0.0001719964,0.0004452086,0.000004712686,0.0001004487,0.0002129918,0.000001612294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001237343,"about_ca_system_score_gemma":0.0001740548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001279903,"about_ca_topic_score_gemma":0.000005333023,"domain_scores_codex":[0.9988034,0.000206036,0.0003223098,0.0003467644,0.00008750495,0.0002339703],"domain_scores_gemma":[0.9991928,0.00006019883,0.0003399018,0.0001949163,0.0001084684,0.0001037118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001887278,0.0003029788,0.0001604951,0.00002303199,0.00008871754,0.000009975254,0.0003376606,0.000890243,0.9963802,0.00003422527,0.00135485,0.000228973],"study_design_scores_gemma":[0.001826611,0.005564256,0.07133047,0.00004162402,0.00003518839,0.00007738809,0.002857455,0.00001033265,0.9165877,0.0004238066,0.001013835,0.0002313174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982136,0.001314371,0.00002763388,0.00009855351,0.0001845729,0.00007465042,0.00001718402,0.000002093281,0.00006729678],"genre_scores_gemma":[0.9959688,0.001788376,0.001738311,0.0002497783,0.00008161853,0.000003557842,0.00004897834,0.00001832767,0.0001023225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0797924,"threshold_uncertainty_score":0.7278598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003108490191755181,"score_gpt":0.2190257756326655,"score_spread":0.2159172854409103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}