{"id":"W3217446559","doi":"10.1152/ajpcell.00130.2021","title":"Mitochondrial bioenergetics of astrocytes in Fragile X syndrome: new perspectives on culture conditions and sex effects","year":2021,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Government of Canada; McMaster University","keywords":"Fragile X syndrome; Oxidative stress; Bioenergetics; Biology; Mitochondrion; Astrocyte; FMR1; Reactive oxygen species; Microglia; Neuroscience; Cell biology; Endocrinology; Internal medicine; Central nervous system; Genetics; Immunology; Medicine; Gene; Fragile x; Inflammation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008031704,0.0003598599,0.0005917097,0.0003044861,0.0003866494,0.000534793,0.0004257842,0.0003332416,0.0009337608],"category_scores_gemma":[0.0003022806,0.0001469505,0.000391638,0.0003748667,0.0004688592,0.0005734997,0.0005506203,0.0008306508,0.0004293763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002685276,"about_ca_system_score_gemma":0.0002896586,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001394188,"about_ca_topic_score_gemma":0.004255959,"domain_scores_codex":[0.9993938,0.0001647591,0.0001042524,0.0001128668,0.0001692042,0.0000551787],"domain_scores_gemma":[0.9997249,0.00006472448,0.00003331975,0.00007016883,0.00007540742,0.00003129919],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003990655,0.0001143509,0.001401871,0.0002599944,0.00001722786,0.00024913,0.000379635,0.0001343198,0.988167,0.0006208135,0.0001836834,0.008072902],"study_design_scores_gemma":[0.00005346162,0.001066806,0.01943054,0.0001428027,0.0001692644,0.001274093,0.0006233566,0.001844718,0.9514582,0.001024486,0.02286617,0.0000462239],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9114797,0.04206065,0.03298004,0.001480081,0.0006406482,0.0001823941,0.00129695,0.000123277,0.009756331],"genre_scores_gemma":[0.9494519,0.01971152,0.02429821,0.0004023532,0.0001735519,0.0003876457,0.001119656,0.00009944354,0.004355721],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001394188,"threshold_uncertainty_score":0.004247606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003108490191755181,"score_gpt":0.2190257756326655,"score_spread":0.2159172854409103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}