{"id":"W3217461843","doi":"10.1182/blood-2021-151467","title":"Elucidating the Importance and Regulation of Key Enhancers for Human MEIS1 Expression","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; BC Cancer Agency","funders":"","keywords":"Enhancer; Biology; CRISPR; Cas9; Genetics; Intron; Enhancer trap; Gene; Molecular biology; Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001525789,0.0001931771,0.0001569904,0.0001874968,0.0001357171,0.000274126,0.0001831756,0.000193501,0.001001365],"category_scores_gemma":[0.0001371075,0.0001200254,0.0001740877,0.0001280545,0.0001698606,0.0001293848,0.0002088005,0.0004562181,0.0003596934],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002886901,"about_ca_system_score_gemma":0.0001894921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000675156,"about_ca_topic_score_gemma":0.0009580348,"domain_scores_codex":[0.9999021,0.00001047874,0.000006863072,0.00003755305,0.00002450891,0.00001833773],"domain_scores_gemma":[0.9999256,0.00002207511,0.00001839596,0.000009259602,0.000008859231,0.00001585105],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005810371,0.000007789145,0.0004713433,0.00001447043,0.000001377343,0.0000205994,0.00001599491,0.0001050078,0.9981456,0.0001433215,0.00002110853,0.0009952625],"study_design_scores_gemma":[0.000005530613,0.0000407115,0.007107549,0.000004018391,0.000004819306,0.0001083366,0.0000187962,0.001629422,0.9886903,0.00007596935,0.002311102,0.000003384473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837068,0.00153735,0.01250868,0.0001074062,0.00001843689,0.00003148205,0.0008066659,0.00009115324,0.001192056],"genre_scores_gemma":[0.9900697,0.0004676585,0.006434523,0.00004832019,0.00000774472,0.00003108219,0.001093547,0.00002481288,0.001822658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001001365,"threshold_uncertainty_score":0.0033499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0230980652139318,"score_gpt":0.3156076905347915,"score_spread":0.2925096253208597,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}