{"id":"W3217474359","doi":"10.1016/j.prp.2021.153723","title":"Cancer immunotherapy: Challenges and limitations","year":2021,"lang":"en","type":"review","venue":"Pathology - Research and Practice","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Immunosurveillance; Immunotherapy; Oncolytic virus; Cancer; Cancer immunotherapy; Medicine; Acquired resistance; Cancer research; Oncology; Immunology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01109547,0.00141016,0.004380704,0.003067098,0.0008545333,0.005148047,0.002458662,0.004272249,0.007707035],"category_scores_gemma":[0.009821672,0.0006345777,0.001183455,0.003208212,0.003194089,0.007393706,0.003667122,0.00755456,0.003095459],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002914593,"about_ca_system_score_gemma":0.008007686,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002446936,"about_ca_topic_score_gemma":0.006672382,"domain_scores_codex":[0.9979627,0.0007899406,0.0002458344,0.0002452623,0.0005884345,0.0001679373],"domain_scores_gemma":[0.9878149,0.008483227,0.0006551858,0.0002468773,0.002213554,0.0005862387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001416533,0.00007129687,0.0001994447,0.02773624,0.0001436483,0.00009065716,0.0001213424,0.0004711727,0.0003886692,0.01963279,0.08917253,0.8618306],"study_design_scores_gemma":[0.00005013057,0.0001024728,0.0003437038,0.02076375,0.0001621542,0.0003019031,0.0002195795,0.0002036905,0.0001135191,0.01078104,0.9669282,0.00002979153],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000195656,0.9958793,0.0001152307,0.003050778,0.0005144889,0.000003239941,0.0000113571,0.000006877636,0.00039913],"genre_scores_gemma":[0.000505908,0.995139,0.0003628222,0.002346752,0.001306934,0.00001572123,0.00002081584,0.000003499246,0.0002984083],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01109547,"threshold_uncertainty_score":0.0586791,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.503183840981943,"score_gpt":0.5564164942590247,"score_spread":0.05323265327708171,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}