{"id":"W3217481197","doi":"10.1182/blood-2021-153445","title":"Constrained FL: A Genetically Distinct Subgroup of Follicular Lymphoma with Low Rates of Somatic Hypermutation and a Reduced Propensity for Histologic Transformation","year":2021,"lang":"en","type":"article","venue":"Blood","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; Simon Fraser University; University of British Columbia; Spinal Cord Injury BC","funders":"","keywords":"Somatic hypermutation; BCL6; Biology; Follicular lymphoma; Germinal center; Somatic cell; Genetics; Lymphoma; Cell of origin; Diffuse large B-cell lymphoma; Fluorescence in situ hybridization; Cancer research; Gene; B cell; Chromosome; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494131,0.0003780467,0.0002812656,0.0009377662,0.0003015524,0.0006057295,0.000330962,0.0003358526,0.003870915],"category_scores_gemma":[0.0005810632,0.000118965,0.0001481834,0.0005806335,0.0002969475,0.0002510278,0.0003984757,0.000192152,0.0005769916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003179201,"about_ca_system_score_gemma":0.0001624256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217829,"about_ca_topic_score_gemma":0.001209287,"domain_scores_codex":[0.9998338,0.00001400257,0.00001958575,0.00006579908,0.0000298936,0.00003691726],"domain_scores_gemma":[0.9997868,0.00003278785,0.0000854447,0.000029157,0.00002485279,0.00004093907],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001608438,0.000121737,0.7471899,0.0001081263,0.000124396,0.008817483,0.0003034988,0.0003324267,0.210564,0.0004050835,0.0007397581,0.02968525],"study_design_scores_gemma":[0.0001024096,0.0005040764,0.9264036,0.00001732856,0.00009668856,0.05626485,0.0004482605,0.0009000713,0.01073819,0.0006862935,0.003812607,0.00002563121],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981387,0.0001402034,0.0004086962,0.00002100683,0.00000168493,0.00002013277,0.0003575958,0.0000293425,0.0008827063],"genre_scores_gemma":[0.9989274,0.00002100241,0.00026677,0.00001565004,0.000005655234,0.000009883496,0.0005648618,0.000009277764,0.0001795108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003870915,"threshold_uncertainty_score":0.01294947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613062665789393,"score_gpt":0.2415695368399892,"score_spread":0.2254389101820953,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}