{"id":"W3217486258","doi":"10.3390/ijerph182212159","title":"Associations between Brain Reserve Proxies and Clinical Progression in Alzheimer’s Disease Dementia","year":2021,"lang":"en","type":"article","venue":"International Journal of Environmental Research and Public Health","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Chosun University; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; U.S. Department of Defense; Meso Scale Diagnostics; F. Hoffmann-La Roche; University of Southern California; Biogen; BioClinica; Eli Lilly and Company; Bristol-Myers Squibb; Foundation for the National Institutes of Health","keywords":"Cognitive reserve; Dementia; Alzheimer's disease; Disease; Medicine; Neuroscience; Psychology; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001088802,0.0004359253,0.0003750206,0.0009684187,0.0002640404,0.0005782653,0.0003155614,0.0003657506,0.0007520714],"category_scores_gemma":[0.004207833,0.000165573,0.000392264,0.0006266088,0.0002279992,0.0004631138,0.0003919941,0.0007108367,0.00008587985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001507524,"about_ca_system_score_gemma":0.0001556492,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002105923,"about_ca_topic_score_gemma":0.00303321,"domain_scores_codex":[0.9997479,0.0001004748,0.00002655047,0.00004987165,0.00003779081,0.00003733056],"domain_scores_gemma":[0.9980239,0.0005579449,0.0009068527,0.0001686606,0.0001676902,0.0001751352],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001239272,0.00007762747,0.9927666,0.00003339745,0.0001598427,0.0001502533,0.00008919986,0.0001535028,0.0003230594,0.00005848536,0.00005117005,0.004897583],"study_design_scores_gemma":[0.000009065383,0.0001542494,0.998868,0.000008214342,0.0000677202,0.0001935305,0.00006846941,0.0003018719,0.0001001153,0.0001352097,0.00009002091,0.000003483882],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984421,0.0009152507,0.0001247616,0.00002541174,0.000005115336,0.00000530877,0.00009606868,0.00000377215,0.0003822662],"genre_scores_gemma":[0.9995937,0.0001079347,0.00008157884,0.000005933529,0.000007624079,0.000003190829,0.0001142511,0.000001029358,0.00008483496],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002105923,"threshold_uncertainty_score":0.005758166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1560211732267273,"score_gpt":0.5052660085655468,"score_spread":0.3492448353388194,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}