{"id":"W3217494602","doi":"10.3390/diagnostics11122171","title":"Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm","year":2021,"lang":"en","type":"article","venue":"Diagnostics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Circulating tumor DNA; Cancer; Holy Grail; Stage (stratigraphy); Internal medicine; Oncology; Medicine; Clinical significance; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01864187,0.001503738,0.002737986,0.00285841,0.0008066138,0.005802529,0.002764789,0.005306584,0.004441016],"category_scores_gemma":[0.04488161,0.0008626806,0.000853049,0.0008609704,0.006456445,0.00905505,0.002920627,0.004662604,0.004229577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002494314,"about_ca_system_score_gemma":0.002536155,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001154155,"about_ca_topic_score_gemma":0.0008563832,"domain_scores_codex":[0.9909528,0.003770286,0.0003726837,0.00167605,0.002670703,0.000557418],"domain_scores_gemma":[0.9652064,0.02383935,0.002180309,0.002137762,0.005341387,0.001294821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00418689,0.0006153241,0.05338865,0.003206761,0.0005545836,0.001354097,0.0009468884,0.002804849,0.0269378,0.1275866,0.04925889,0.7291586],"study_design_scores_gemma":[0.0008686088,0.008976659,0.01937885,0.004207171,0.001278171,0.01009823,0.001528296,0.03462981,0.06420361,0.3085039,0.5454744,0.0008523121],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.08053074,0.3247642,0.1435701,0.3945107,0.01177723,0.0004131971,0.001304649,0.001602052,0.04152709],"genre_scores_gemma":[0.6711405,0.06542054,0.09990638,0.1304593,0.01462018,0.0006819261,0.001032608,0.0004993924,0.01623921],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.01864187,"threshold_uncertainty_score":0.09858882,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281846789069532,"score_gpt":0.2577526899479861,"score_spread":0.2449342220572908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}