{"id":"W3217494602","doi":"10.3390/diagnostics11122171","title":"Can Circulating Tumor DNA Support a Successful Screening Test for Early Cancer Detection? The Grail Paradigm","year":2021,"lang":"en","type":"article","venue":"Diagnostics","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network; Mount Sinai Hospital","funders":"","keywords":"Circulating tumor DNA; Cancer; Holy Grail; Stage (stratigraphy); Internal medicine; Oncology; Medicine; Clinical significance; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001494727,0.0002076969,0.0001849948,0.00002611968,0.0003244281,0.0001373979,0.0002200707,0.000102199,0.00002925314],"category_scores_gemma":[0.002347686,0.0001932515,0.0001535794,0.0001610234,0.00008511091,0.000004271426,0.0001364513,0.0001280119,0.000003406956],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003765677,"about_ca_system_score_gemma":0.0003772519,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004153937,"about_ca_topic_score_gemma":0.00430083,"domain_scores_codex":[0.9986906,0.00002901169,0.0002873758,0.0004295395,0.0001479527,0.0004155374],"domain_scores_gemma":[0.9983883,0.0006725904,0.0001407532,0.0004350293,0.000238076,0.0001252796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001467587,0.0004997685,0.7072526,0.000231179,0.0005979867,0.000299771,0.0009055858,0.004591083,0.2145684,0.001489753,0.02216929,0.04724787],"study_design_scores_gemma":[0.002651907,0.0008388146,0.1610485,0.0001289911,0.0004731754,0.0001936401,0.0005921851,0.001580581,0.6160209,0.001772431,0.2134361,0.001262777],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855151,0.002038767,0.008180366,0.00178281,0.0007220819,0.0004865608,0.0009849221,0.00002484127,0.0002645983],"genre_scores_gemma":[0.9949024,0.0008837448,0.0004929068,0.001882135,0.001056918,0.0003139283,0.0002462851,0.00005659295,0.0001651042],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.546204,"threshold_uncertainty_score":0.7880569,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281846789069532,"score_gpt":0.2577526899479861,"score_spread":0.2449342220572908,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}