{"id":"W3217529080","doi":"10.1053/j.gastro.2021.11.028","title":"γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; American-Italian Cancer Foundation; National Institutes of Health; New Jersey Health Foundation","keywords":"Granzyme B; Intraepithelial lymphocyte; Granzyme; Pathological; Cell biology; Chemistry; Cancer research; Epithelium; Immunology; Biology; Medicine; Pathology; Perforin; Antigen; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002012491,0.0005131104,0.0003247035,0.0002878941,0.0002629777,0.0009548814,0.0002768987,0.0006075409,0.002881936],"category_scores_gemma":[0.0003260666,0.0001935663,0.0004995565,0.0001051489,0.0003432383,0.0006493788,0.0007296748,0.002080871,0.001088475],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002577765,"about_ca_system_score_gemma":0.0002039747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825801,"about_ca_topic_score_gemma":0.0001762759,"domain_scores_codex":[0.9996732,0.00005367935,0.00002813427,0.00004972574,0.00005808818,0.0001371587],"domain_scores_gemma":[0.9998104,0.00003057507,0.00004094176,0.00004096972,0.00002430853,0.00005280017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007159628,0.00008683836,0.001236423,0.000143439,0.00001506876,0.0007496552,0.000132147,0.0001478023,0.9884264,0.0005919209,0.0002729002,0.007481454],"study_design_scores_gemma":[0.0002337432,0.0009114989,0.01967668,0.000102882,0.00007113022,0.002713314,0.001073155,0.002638142,0.9634885,0.001823047,0.007247482,0.00002041161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878307,0.002185882,0.005111913,0.0005099232,0.0001560078,0.00004955187,0.0001476103,0.0002417439,0.00376661],"genre_scores_gemma":[0.9956851,0.000539423,0.001220491,0.000101577,0.00003040267,0.00002096117,0.00009885216,0.00002972927,0.002273558],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002881936,"threshold_uncertainty_score":0.009641051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041222919110966,"score_gpt":0.200309025851322,"score_spread":0.1898967966602124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}