{"id":"W3217529080","doi":"10.1053/j.gastro.2021.11.028","title":"γδ Intraepithelial Lymphocytes Facilitate Pathological Epithelial Cell Shedding Via CD103-Mediated Granzyme Release","year":2021,"lang":"en","type":"article","venue":"Gastroenterology","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":48,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Center for Research Resources; National Institute of Allergy and Infectious Diseases; National Health and Medical Research Council; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; National Institute of Diabetes and Digestive and Kidney Diseases; American-Italian Cancer Foundation; National Institutes of Health; New Jersey Health Foundation","keywords":"Granzyme B; Intraepithelial lymphocyte; Granzyme; Pathological; Cell biology; Chemistry; Cancer research; Epithelium; Immunology; Biology; Medicine; Pathology; Perforin; Antigen; CD8","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003948055,0.0006011027,0.000980944,0.0002139333,0.0003765242,0.00003353736,0.0005850182,0.0008498391,0.00325821],"category_scores_gemma":[0.0001967393,0.0005391925,0.0003854906,0.0002172294,0.0009990645,0.0001401337,0.0004928523,0.0009603731,0.004593391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001226705,"about_ca_system_score_gemma":0.0001308191,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001059829,"about_ca_topic_score_gemma":0.00008039776,"domain_scores_codex":[0.994766,0.00145979,0.0008938256,0.001130984,0.00008499251,0.001664399],"domain_scores_gemma":[0.9983721,0.0003230482,0.0002758348,0.0006880375,0.0002198285,0.0001211576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001829506,0.0006709439,0.009245601,0.00002681213,0.000200776,0.0007989158,0.0003524214,0.0000204606,0.9832241,0.00007018951,0.001592471,0.001967808],"study_design_scores_gemma":[0.01549944,0.003214872,0.007869701,0.00003458608,0.0002351707,0.004869267,0.000490905,0.00005704121,0.9106517,0.0007113382,0.05563141,0.0007345316],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909357,0.001740805,0.002273181,0.001024812,0.002477471,0.0002603407,0.0003671919,0.0003202356,0.0006002988],"genre_scores_gemma":[0.9930847,0.0004432303,0.0005316893,0.002008331,0.0001520305,0.0000674808,0.0009636367,0.00005084635,0.00269805],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07257236,"threshold_uncertainty_score":0.999706,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01041222919110966,"score_gpt":0.200309025851322,"score_spread":0.1898967966602124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}