{"id":"W3217544539","doi":"10.1016/j.cell.2021.11.016","title":"An NK-like CAR T cell transition in CAR T cell dysfunction","year":2021,"lang":"en","type":"article","venue":"Cell","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":401,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Stand Up To Cancer; National Cancer Institute; National Institutes of Health; Incyte; Parker Institute for Cancer Immunotherapy; Bayer Fund; American Cancer Society; Stand Up To Cancer Canada; AstraZeneca; Celgene; GlaxoSmithKline","keywords":"Chimeric antigen receptor; Biology; T cell; CD8; Cancer research; Mesothelin; T-cell receptor; Immunology; Cell biology; Antigen; Immune system","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003083454,0.000452365,0.0003452664,0.0003952718,0.0004587314,0.001245586,0.0005244976,0.001133271,0.007077738],"category_scores_gemma":[0.0005614783,0.0001871362,0.0003063903,0.0001431901,0.0008824319,0.001044302,0.0006517647,0.001786954,0.001137917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006565768,"about_ca_system_score_gemma":0.0004299454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003308257,"about_ca_topic_score_gemma":0.0002457495,"domain_scores_codex":[0.9996445,0.0000767281,0.00003007132,0.0000748016,0.0000643446,0.0001095711],"domain_scores_gemma":[0.9997583,0.00005030562,0.00005583863,0.00003986248,0.00002978622,0.00006581375],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002490651,0.000405154,0.009015167,0.000443782,0.0000758636,0.01072637,0.0005545654,0.001156355,0.8964615,0.03942666,0.003699505,0.03554449],"study_design_scores_gemma":[0.0002777575,0.002298313,0.02613709,0.0001182022,0.0001996153,0.07524692,0.001245358,0.008654436,0.8014239,0.02106133,0.06328539,0.00005178063],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9647284,0.004941882,0.01063154,0.001938287,0.0003250076,0.0001026829,0.0002973806,0.0006708014,0.01636399],"genre_scores_gemma":[0.996371,0.0002742709,0.0005685583,0.000190875,0.00003852064,0.00001854668,0.00006327909,0.00002271491,0.002452203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007077738,"threshold_uncertainty_score":0.02367735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01910311781100935,"score_gpt":0.2763343176554929,"score_spread":0.2572311998444835,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}