{"id":"W3217582756","doi":"10.3390/nu13114164","title":"Salicylic Acid and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study","year":2021,"lang":"en","type":"article","venue":"Nutrients","topic":"Cholesterol and Lipid Metabolism","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital; Memorial University of Newfoundland","funders":"Office of Research Infrastructure Programs, National Institutes of Health; National Institute of Environmental Health Sciences; National Institute on Aging; Medicinska fakulteten, Umeå Universitet; Health and Social Care Research and Development Division; Instituto de Salud Carlos III; Cancer Council Victoria; Ontario Ministry of Research and Innovation; National Health and Medical Research Council; National Center for Advancing Translational Sciences; Economic and Social Research Council; Medical Research Council; Canadian Institutes of Health Research; NIHR Cambridge Biomedical Research Centre; NIHR BioResource; Centers for Disease Control and Prevention; Chonnam National University Hwasun Hospital; Hellenic Health Foundation; Junta de Castilla y León; Wereld Kanker Onderzoek Fonds; Xunta de Galicia; Mutuelle Générale de l'Education Nationale; Deutsche Krebshilfe; Associazione Italiana per la Ricerca sul Cancro; NordForsk; Vetenskapsrådet; Cambridge University Hospitals; Stockholms Läns Landsting; Chief Scientist Office, Scottish Government Health and Social Care Directorate; Bundesministerium für Bildung und Forschung; British Heart Foundation; Ministerio de Economía y Competitividad; Cancerfonden; National Cancer Institute; Fundación Científica Asociación Española Contra el Cáncer; Cancer Research Foundation in Northern Sweden; Karolinska Institutet; University of Cambridge; ZonMw; Institut Gustave-Roussy; Grantová Agentura České Republiky; Canadian Cancer Society Research Institute; Institut National de la Santé et de la Recherche Médicale; McGill University; Public Health Agency; World Cancer Research Fund; Knut och Alice Wallenbergs Stiftelse; Damon Runyon Cancer Research Foundation; University of Bristol; Ministerstvo Zdravotnictví Ceské Republiky; Engineering and Physical Sciences Research Council; Groupement des Entreprises Françaises dans la lutte contre le Cancer; Centre Hospitalier Universitaire de Nantes; European Commission; Generalitat de Catalunya; Food Standards Agency; Department of Health and Social Care; Xarxa de Bancs de Tumors de Catalunya; World Health Organization; Cancer Research UK; Conseil Régional des Pays de la Loire; Génome Québec; Matthias Lackas-Stiftung; Umeå Universitet; Chonnam National University; Centres de Recerca de Catalunya; University of South Florida; NHS Blood and Transplant; Swedish Cancer Foundation; Moffitt Cancer Center; Pelotonia; Division of Cancer Prevention, National Cancer Institute; Scottish Government; National Heart, Lung, and Blood Institute; Florida Department of Health; National Institutes of Health; Mike and Josie Harper Cancer Research Institute; World Cancer Research Fund International; Memorial Sloan-Kettering Cancer Center; Johns Hopkins University; Association Anne de Bretagne Genetique; Agència de Gestió d'Ajuts Universitaris i de Recerca; National Institute for Health and Care Research; Fred Hutchinson Cancer Research Center; Ligue Contre le Cancer; Deutsches Krebsforschungszentrum; U.S. Department of Health and Human Services","keywords":"Mendelian randomization; Aspirin; Single-nucleotide polymorphism; Colorectal cancer; Medicine; Genome-wide association study; Salicylic acid; Internal medicine; Bioinformatics; Oncology; Biology; Genetics; Cancer; Genotype; Gene; Genetic variants","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007537236,0.0007822993,0.0010859,0.000621108,0.0005040485,0.0005604236,0.0006979948,0.001011444,0.002589636],"category_scores_gemma":[0.01430886,0.0005376716,0.001380344,0.0009450129,0.0004902829,0.0003471503,0.0003683571,0.0005868109,0.0002824296],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003512197,"about_ca_system_score_gemma":0.0004978051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002452008,"about_ca_topic_score_gemma":0.001580011,"domain_scores_codex":[0.9914665,0.005894747,0.0003627519,0.001402737,0.0006171344,0.0002561212],"domain_scores_gemma":[0.9953018,0.001835528,0.0008218455,0.001550439,0.0002512187,0.0002391627],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0695991,0.001386034,0.8625329,0.0005097971,0.01333734,0.002229501,0.0008312647,0.002144153,0.01308743,0.004503264,0.002735231,0.02710396],"study_design_scores_gemma":[0.01542003,0.01620851,0.902617,0.0001169191,0.01135782,0.005167464,0.0003367175,0.03561659,0.002118841,0.005114458,0.005720085,0.0002056717],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9878942,0.0008463346,0.009251131,0.000211408,0.00006091168,0.0003811187,0.0006004393,0.00007483246,0.0006796197],"genre_scores_gemma":[0.994756,0.0001069397,0.00403943,0.00009441594,0.00002820211,0.0002275445,0.0003236222,0.00001828388,0.0004055069],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007537236,"threshold_uncertainty_score":0.03986114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282334029395969,"score_gpt":0.2901850955374755,"score_spread":0.2773617552435158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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