{"id":"W3217590704","doi":"10.1038/s41586-021-04091-0","title":"The human microbiome encodes resistance to the antidiabetic drug acarbose","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Office of Science; National Institutes of Health; Wellcome Trust; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Vallee Foundation; Princeton University; Brookhaven National Laboratory; U.S. Department of Energy","keywords":"Acarbose; Microbiome; Biology; Metagenomics; Human microbiome; Enzyme; Bacteria; Computational biology; Biochemistry; Microbiology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002242852,0.0001136675,0.00007659828,0.00001172793,0.0003357018,0.0000770146,0.0004589412,0.0004279083,0.00001007706],"category_scores_gemma":[0.0001987818,0.00006545922,0.0000953439,0.0002100629,0.0001094448,0.000001133939,0.0003222123,0.0008261481,0.00001950362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001038768,"about_ca_system_score_gemma":0.00007244422,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000296005,"about_ca_topic_score_gemma":0.0001798152,"domain_scores_codex":[0.9989724,0.0001024739,0.0001044475,0.0003304973,0.0001863077,0.0003039378],"domain_scores_gemma":[0.9991041,0.00002105517,0.00002282624,0.0006105581,0.0001614718,0.00007998633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001459136,0.00001743697,0.00006471069,0.000009101431,0.00002504957,0.000008250293,0.00002033309,4.706305e-7,0.9049832,0.0002981167,0.09413374,0.0004249999],"study_design_scores_gemma":[0.00007042773,0.000008045858,0.0003228364,0.00000810959,0.000003776138,0.000003375248,0.0000248862,2.12949e-7,0.5502352,0.00009373626,0.4491702,0.00005919969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.949295,0.02711227,0.00002214641,0.02067771,0.0001708944,0.0001819673,0.00002913572,0.00001027225,0.002500539],"genre_scores_gemma":[0.975397,0.000295168,0.0001498662,0.003193717,0.0002619933,0.00002124052,0.00007873833,0.00001680564,0.02058547],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3550364,"threshold_uncertainty_score":0.3589248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004472211662941808,"score_gpt":0.2732162610196988,"score_spread":0.2687440493567569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}