{"id":"W3217590704","doi":"10.1038/s41586-021-04091-0","title":"The human microbiome encodes resistance to the antidiabetic drug acarbose","year":2021,"lang":"en","type":"article","venue":"Nature","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":88,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; Office of Science; National Institutes of Health; Wellcome Trust; National Institute of General Medical Sciences; Canadian Institute for Advanced Research; Biological and Environmental Research; National Institute of Allergy and Infectious Diseases; Vallee Foundation; Princeton University; Brookhaven National Laboratory; U.S. Department of Energy","keywords":"Acarbose; Microbiome; Biology; Metagenomics; Human microbiome; Enzyme; Bacteria; Computational biology; Biochemistry; Microbiology; Genetics; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272786,0.0002961276,0.0002067676,0.0003519352,0.0002755569,0.0005302578,0.00008652943,0.0005695989,0.002461613],"category_scores_gemma":[0.0007480337,0.0001811951,0.0002112646,0.0003457982,0.0002376534,0.0001575276,0.0003337016,0.0004949006,0.0003905711],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001657025,"about_ca_system_score_gemma":0.0002196884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001030242,"about_ca_topic_score_gemma":0.0009040379,"domain_scores_codex":[0.999819,0.00004673702,0.0000084108,0.00004278568,0.00004946319,0.00003357922],"domain_scores_gemma":[0.9997212,0.00006095369,0.0001175609,0.00001789627,0.00002850112,0.00005391784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002241553,0.0001261255,0.1648824,0.0003991383,0.0003409061,0.002972635,0.000391494,0.0004274084,0.7471731,0.002536186,0.006647652,0.07186147],"study_design_scores_gemma":[0.0001356597,0.0006130213,0.8331173,0.0002739931,0.0003849647,0.01300558,0.001036692,0.001970977,0.1018985,0.003949526,0.04353588,0.00007798889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9808688,0.006177061,0.001928285,0.002774094,0.0003011393,0.00001499301,0.00265093,0.0001477565,0.005137015],"genre_scores_gemma":[0.9919007,0.003160376,0.00156125,0.0003531635,0.00007445773,0.00001123451,0.0007774286,0.00003194432,0.002129426],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002461613,"threshold_uncertainty_score":0.008234918,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004472211662941808,"score_gpt":0.2732162610196988,"score_spread":0.2687440493567569,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}