{"id":"W3217595412","doi":"10.1101/gr.275953.121","title":"Delayed DNA replication in haploid human embryonic stem cells","year":2021,"lang":"en","type":"article","venue":"Genome Research","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; New York State Stem Cell Science; Rosetrees Trust; Cornell University","keywords":"Biology; Ploidy; Genetics; Replication timing; DNA replication; Chromosome; Mitosis; Control of chromosome duplication; Embryonic stem cell; Gene duplication; Cell biology; DNA; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008979693,0.00009920978,0.000118185,0.00008973658,0.0001398296,0.00005197998,0.0003081519,0.0001487328,0.00004365555],"category_scores_gemma":[0.00002334587,0.0001116602,0.00005707412,0.0002795846,0.00006160075,0.00000228707,0.0003392907,0.0002165248,0.00007225845],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009072254,"about_ca_system_score_gemma":0.0002385165,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003080919,"about_ca_topic_score_gemma":0.0002642544,"domain_scores_codex":[0.9983875,0.0001817703,0.0002140911,0.0005639867,0.0002249516,0.000427752],"domain_scores_gemma":[0.9986304,0.00001412033,0.00003846015,0.0009986802,0.0002282936,0.00009003651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000126134,0.00006543908,0.0002947577,0.00002386375,0.00001813641,0.00001477308,0.00005656107,0.0001187646,0.9980112,0.0002421798,0.0002910322,0.000850687],"study_design_scores_gemma":[0.0006074512,0.0002549469,0.007654136,0.00001208065,0.000004621862,0.00002258963,0.0004285221,0.0003736487,0.9545393,0.0005139355,0.03533708,0.000251702],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958691,0.001217166,0.0001136295,0.0002445744,0.00003582729,0.0001921407,0.00002219008,0.000006932589,0.002298468],"genre_scores_gemma":[0.9920431,0.0005635898,0.0002713572,0.00004316575,0.000106805,0.00004391799,0.0002657869,0.00002931471,0.006633005],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0434719,"threshold_uncertainty_score":0.4553373,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03786756826700399,"score_gpt":0.3297089037742179,"score_spread":0.2918413355072139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}