{"id":"W3217622676","doi":"10.3390/ijms222212513","title":"Characterizing the NLRP3 Inflammasome in Mood Disorders: Overview, Technical Development, and Measures of Peripheral Activation in Adolescent Patients","year":2021,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"University of Toronto; Ontario Mental Health Foundation","keywords":"Inflammasome; Pyrin domain; Intracellular; Caspase 1; Peripheral blood mononuclear cell; Medicine; Mood disorders; Inflammation; Biology; Immunology; Cell biology; Biochemistry; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001464042,0.0004970207,0.0005267308,0.0008871563,0.0002160924,0.0005703758,0.0002805823,0.0004156453,0.0005890331],"category_scores_gemma":[0.001522298,0.0002182733,0.0002456522,0.0008192264,0.0003224611,0.0002688499,0.0003668344,0.0006091148,0.0003524054],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003012941,"about_ca_system_score_gemma":0.0002974167,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005465351,"about_ca_topic_score_gemma":0.0009477016,"domain_scores_codex":[0.9990125,0.000320989,0.0001559483,0.0001839302,0.0002714934,0.00005519222],"domain_scores_gemma":[0.9991696,0.0001857283,0.0002639368,0.00003618679,0.0002833118,0.00006126276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002182679,0.000581338,0.5015086,0.001907154,0.000179612,0.0021157,0.001024906,0.0004196095,0.2162093,0.000408279,0.001569562,0.2718932],"study_design_scores_gemma":[0.00008412241,0.004428604,0.8804553,0.0005511594,0.000309535,0.01363411,0.0008689614,0.001552845,0.08454145,0.0003600353,0.01316893,0.00004500168],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8791524,0.0747375,0.03743889,0.0008635505,0.0001771481,0.0008523803,0.001602496,0.000411773,0.004763863],"genre_scores_gemma":[0.9095644,0.03874487,0.04718613,0.0005259505,0.0001757936,0.0007444955,0.001336244,0.00007245374,0.001649618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001464042,"threshold_uncertainty_score":0.007742643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01819177678457982,"score_gpt":0.2708115632317232,"score_spread":0.2526197864471433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}