{"id":"W3217646444","doi":"10.1542/peds.2021-052822","title":"Maximizing Benefits and Minimizing Harms: Diagnostic Uncertainty Arising From Newborn Screening","year":2021,"lang":"en","type":"letter","venue":"PEDIATRICS","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; University of Toronto; Newborn Screening Ontario; Institute for Clinical Evaluative Sciences; Children's Hospital of Eastern Ontario; Hospital for Sick Children; University of Ottawa","funders":"","keywords":"Medicine; Intensive care medicine; Newborn screening; Risk analysis (engineering); Pediatrics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1911041,0.001657014,0.003956221,0.004283613,0.005938518,0.01402928,0.005342906,0.01313849,0.005276902],"category_scores_gemma":[0.5086025,0.001358216,0.00194515,0.002815197,0.02809387,0.02020841,0.01187214,0.01713545,0.0005353173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01495022,"about_ca_system_score_gemma":0.02141341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008515316,"about_ca_topic_score_gemma":0.01060721,"domain_scores_codex":[0.7282663,0.2308007,0.008405727,0.006419362,0.02307198,0.003036],"domain_scores_gemma":[0.2975052,0.6676643,0.01520061,0.006642278,0.009955756,0.003031909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001839585,0.0003692988,0.0320886,0.01209466,0.002559103,0.0035007,0.01975065,0.009662127,0.0004152669,0.3362568,0.05549916,0.5259641],"study_design_scores_gemma":[0.0001583296,0.0003794049,0.004892533,0.010121,0.0005157515,0.00163758,0.006111235,0.003818671,0.0004160695,0.9433578,0.02839186,0.0001997471],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.02156913,0.08620226,0.04210193,0.8257143,0.001840842,0.0004041276,0.000492327,0.00007558205,0.02159945],"genre_scores_gemma":[0.728452,0.05367519,0.03992937,0.1679353,0.007975553,0.0008639906,0.0002430158,0.00009834714,0.0008272606],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1911041,"threshold_uncertainty_score":0.9975127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03846237636399272,"score_gpt":0.2833649329567441,"score_spread":0.2449025565927514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}