{"id":"W3217690404","doi":"10.1161/atvbaha.121.316902","title":"PCSK9 (Proprotein Convertase Subtilisin/Kexin Type 9) Triggers Vascular Smooth Muscle Cell Senescence and Apoptosis: Implication of Its Direct Role in Degenerative Vascular Disease","year":2021,"lang":"en","type":"article","venue":"Arteriosclerosis Thrombosis and Vascular Biology","topic":"Lipoproteins and Cardiovascular Health","field":"Medicine","cited_by":74,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Canadian Institutes of Health Research","keywords":"Vascular smooth muscle; Senescence; Vascular disease; PCSK9; Degenerative disease; Blood vessel; Degenerative Disorder; Cell; Smooth muscle; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008723739,0.000415196,0.001184752,0.0001796403,0.0001701401,0.00004229488,0.000125768,0.0002866065,0.00006754517],"category_scores_gemma":[0.0001435671,0.0003691253,0.0004773236,0.0005124524,0.000238471,0.0001548167,0.0001521901,0.0002382016,0.000008347994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007953598,"about_ca_system_score_gemma":0.0002783883,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005468294,"about_ca_topic_score_gemma":0.00008719109,"domain_scores_codex":[0.9967776,0.0006275013,0.000648183,0.001065552,0.0003451251,0.0005360693],"domain_scores_gemma":[0.9980037,0.00004713773,0.0001820793,0.0009981465,0.0003508893,0.000418024],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00003478571,0.0006018854,0.06220271,0.0007502477,0.0005228054,0.000001370927,0.0005987807,0.000009335647,0.9293503,0.0001644844,0.00002066202,0.005742676],"study_design_scores_gemma":[0.003217097,0.0003962257,0.914221,0.0003432889,0.0005989079,8.060576e-7,0.0004153855,0.0003574523,0.07717917,0.00003718763,0.002829786,0.0004036329],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9849697,0.01294877,0.0002205484,0.0004090816,0.0001075937,0.001188501,0.0000528106,0.00004217987,0.0000607883],"genre_scores_gemma":[0.9653388,0.03322814,0.0005720946,0.000361872,0.00008444482,0.0001895576,0.0001692104,0.00005033815,0.000005497713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8521711,"threshold_uncertainty_score":0.9998761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02156218326372568,"score_gpt":0.2647050624158852,"score_spread":0.2431428791521595,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}