{"id":"W3217691635","doi":"10.3389/fncel.2021.761813","title":"Molecular Investigation of Chicken Acid-Sensing Ion Channel 1 β11-12 Linker Isomerization and Channel Kinetics","year":2021,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Western Canada Research Grid; Compute Canada","keywords":"Molecular dynamics; Kinetics; Chemistry; Acid-sensing ion channel; Ion channel; Biophysics; Linker; Deprotonation; Aspartic acid; Amino acid; Chemical physics; Ion; Computational chemistry; Physics; Biochemistry; Biology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001594099,0.0001362668,0.0001445324,0.0001322645,0.00006654344,0.00002933642,0.00008829064,0.0001430927,0.000001087556],"category_scores_gemma":[0.0001834963,0.0001536479,0.00004178433,0.000375772,0.0001927699,0.00001768518,0.0000895634,0.00008628831,3.457808e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001400241,"about_ca_system_score_gemma":0.00005213309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002859328,"about_ca_topic_score_gemma":0.000002376761,"domain_scores_codex":[0.9987888,0.0001067516,0.0002489986,0.000450246,0.0002113434,0.0001938782],"domain_scores_gemma":[0.9994569,0.000003825074,0.0001268371,0.0002250343,0.0001092704,0.00007813068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000175952,0.00002122637,0.001003574,0.00002400212,0.000002288861,0.000007549179,0.0001217241,0.003421045,0.9946462,0.00002015313,0.00009837357,0.0006163042],"study_design_scores_gemma":[0.0003186007,0.0001047312,0.003480199,0.00002521745,0.000007402024,0.00001307212,0.0001040617,0.05880617,0.9360951,0.0003171332,0.0005832351,0.0001451467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.6821286,0.0005580416,0.3152654,0.0002200852,0.00161865,0.0001232158,0.000004380502,0.000008873404,0.0000727614],"genre_scores_gemma":[0.9972502,0.0002428623,0.001707025,0.0003919014,0.0001138586,0.000002892792,0.0001124989,0.00001803736,0.0001607385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3151216,"threshold_uncertainty_score":0.6265581,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01368889270647777,"score_gpt":0.2095517231561818,"score_spread":0.195862830449704,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}