{"id":"W3217693311","doi":"10.3389/fimmu.2021.780400","title":"SMAC Mimetics as Therapeutic Agents in HIV Infection","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Apoptosis; Caspase; Human immunodeficiency virus (HIV); Virology; Biology; Endogeny; Antiretroviral therapy; Programmed cell death; Cell biology; Medicine; Viral load; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001587181,0.0003469643,0.001001756,0.0003668635,0.00002768249,0.00002029763,0.0003344028,0.0009401472,0.00005235768],"category_scores_gemma":[0.00006852538,0.0003472751,0.0003096659,0.0002989042,0.0001053337,0.000003706485,0.0001955695,0.0004743664,0.0000668768],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001173924,"about_ca_system_score_gemma":0.0003015726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007540345,"about_ca_topic_score_gemma":0.00005671769,"domain_scores_codex":[0.9980645,0.0004083129,0.0005267779,0.0005549666,0.00006998818,0.0003754182],"domain_scores_gemma":[0.9992172,0.00001274483,0.0001783728,0.0005212554,0.00004343476,0.00002695121],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003394709,0.0001459792,0.001871679,0.0005472441,0.0006037051,0.00006437212,0.00004218205,0.000006420173,0.0001709661,0.00003367599,0.007937969,0.9885418],"study_design_scores_gemma":[0.0003074651,0.0001830429,0.0001831456,0.001176321,0.0001083739,0.00006073244,0.00004245103,0.000004430515,0.0002333229,0.00007780395,0.9972948,0.0003280937],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002241613,0.9939377,0.0005629066,0.00001590613,0.002337764,0.0003021545,0.00001246633,0.000007459944,0.0005820552],"genre_scores_gemma":[0.0003118583,0.996646,0.0002691888,0.0001171599,0.0001053273,0.000103459,0.000684147,0.00004361074,0.001719258],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9893569,"threshold_uncertainty_score":0.9998979,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147920107749003,"score_gpt":0.3174698664239837,"score_spread":0.2859906653464937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}