{"id":"W3217693311","doi":"10.3389/fimmu.2021.780400","title":"SMAC Mimetics as Therapeutic Agents in HIV Infection","year":2021,"lang":"en","type":"review","venue":"Frontiers in Immunology","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; Ottawa Hospital; University of Ottawa","funders":"","keywords":"Apoptosis; Caspase; Human immunodeficiency virus (HIV); Virology; Biology; Endogeny; Antiretroviral therapy; Programmed cell death; Cell biology; Medicine; Viral load; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005048427,0.0007836164,0.001132148,0.001721545,0.0002284341,0.0007751557,0.0007918092,0.001058029,0.002818797],"category_scores_gemma":[0.0004443374,0.0002872739,0.0004050626,0.001333112,0.0003920973,0.001030276,0.0005729921,0.002450461,0.002074252],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004623124,"about_ca_system_score_gemma":0.0004143347,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004413937,"about_ca_topic_score_gemma":0.0007566296,"domain_scores_codex":[0.9998754,0.00002424644,0.00001568945,0.00001820194,0.0000499772,0.0000164898],"domain_scores_gemma":[0.9998764,0.00006093473,0.00001752159,0.00000398658,0.00002560465,0.00001548313],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00014136,0.0001424664,0.0001010742,0.01245776,0.00007426528,0.0003296415,0.00006435907,0.0005343679,0.005204241,0.005975891,0.02875073,0.9462239],"study_design_scores_gemma":[0.00002814536,0.0001640171,0.0003683157,0.001629628,0.00005744215,0.000964866,0.0000230063,0.00009509001,0.001046851,0.001549596,0.9940594,0.00001368306],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000185065,0.9981247,0.0001316,0.0001458969,0.0002213688,0.00000812688,0.00001542284,0.000009769161,0.001158172],"genre_scores_gemma":[0.0008819686,0.9976346,0.0002230236,0.0001851595,0.0001616005,0.00001304169,0.00003169616,0.000002170232,0.00086664],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002818797,"threshold_uncertainty_score":0.009429812,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03147920107749003,"score_gpt":0.3174698664239837,"score_spread":0.2859906653464937,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}