{"id":"W3217700626","doi":"10.1002/1878-0261.13141","title":"The TRAR gene classifier to predict response to neoadjuvant therapy in HER2‐positive and ER‐positive breast cancer patients: an explorative analysis from the NeoSphere trial","year":2021,"lang":"en","type":"article","venue":"Molecular Oncology","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hôpital du Saint-Sacrement","funders":"Associazione Italiana per la Ricerca sul Cancro; International Breast Cancer Research Foundation; F. Hoffmann-La Roche; Breast Cancer Research Foundation","keywords":"Oncology; Breast cancer; Medicine; Internal medicine; Neoadjuvant therapy; Bioinformatics; Gynecology; Cancer; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009477461,0.0002736591,0.000666338,0.0001246462,0.0002161697,0.00008432505,0.000290465,0.0002185722,0.0002504655],"category_scores_gemma":[0.0004513535,0.0001746355,0.0001638454,0.001496765,0.0002367004,0.00009412588,0.0001837425,0.0005469255,0.00001114497],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009083763,"about_ca_system_score_gemma":0.00142651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003054732,"about_ca_topic_score_gemma":0.00859999,"domain_scores_codex":[0.9940998,0.003496632,0.0004566556,0.0007885866,0.0006067407,0.000551604],"domain_scores_gemma":[0.9972159,0.0009903639,0.00009840255,0.0006621543,0.0006281337,0.0004050156],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4367687,0.002228376,0.02537154,0.000006456748,0.00414425,0.003076274,0.03469991,0.0005459129,0.08601815,0.00008331094,0.003071517,0.4039856],"study_design_scores_gemma":[0.04516642,0.01654958,0.8666567,0.0001558346,0.0007391301,0.00003486162,0.008376731,0.0006517036,0.0365076,0.0001324868,0.02453416,0.0004947564],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523996,0.001284677,0.0006675148,0.04242054,0.0002188423,0.002212831,0.0005934804,0.00001818362,0.0001842971],"genre_scores_gemma":[0.9866682,0.0005368575,0.0003772775,0.01060059,0.0002597717,0.001158786,0.0001419291,0.00005153954,0.0002050367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8412852,"threshold_uncertainty_score":0.7121427,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02953605829063439,"score_gpt":0.3724926566946314,"score_spread":0.3429565984039971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}