{"id":"W3217725760","doi":"10.1161/circ.144.suppl_1.12802","title":"Abstract 12802: Intron-Mediated Enhancement of <i>Titin</i> ( <i>TTN</i> ) Regulates Sarcomere Formation and Function","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Congenital heart defects research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Enhancer; Sarcomere; Titin; Mef2; Transcription factor; Cell biology; Biology; Induced pluripotent stem cell; Enhancer RNAs; Gene expression; Molecular biology; Gene; Genetics; Myocyte; Embryonic stem cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001107497,0.000312682,0.0001614346,0.0001516878,0.0001094939,0.00008940235,0.0001193945,0.0001753123,0.002415634],"category_scores_gemma":[0.0001465708,0.00006235122,0.0001627332,0.0000964327,0.0002119153,0.0000504958,0.0001350486,0.0002225451,0.0006748529],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009568206,"about_ca_system_score_gemma":0.0001186254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002376634,"about_ca_topic_score_gemma":0.0002221345,"domain_scores_codex":[0.9999459,0.000007993192,0.000005567603,0.00001886743,0.00001321101,0.00000839426],"domain_scores_gemma":[0.9999224,0.0000186406,0.00002448207,0.000006436578,0.000006537889,0.00002148321],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000687918,0.0000874588,0.01539991,0.00007318029,0.00001893875,0.000951671,0.00004344754,0.0001450553,0.9748942,0.0001204752,0.0004168771,0.007160913],"study_design_scores_gemma":[0.0002362797,0.002125955,0.3445941,0.00004041213,0.0001273061,0.01776659,0.00006925503,0.00223798,0.6223162,0.0002517459,0.01021532,0.00001890803],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9948945,0.000212921,0.002577253,0.00006956817,0.0000127073,0.00002334386,0.001022614,0.0000687723,0.001118262],"genre_scores_gemma":[0.9928365,0.0002151346,0.001983316,0.00006552367,0.00002526018,0.00003899648,0.002993542,0.00004105144,0.001800636],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415634,"threshold_uncertainty_score":0.008081079,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01102891801569185,"score_gpt":0.2478383004048413,"score_spread":0.2368093823891495,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}