{"id":"W3217753220","doi":"10.3390/brainsci11121583","title":"Novel Approaches in the Immunotherapy of Multiple Sclerosis: Cyclization of Myelin Epitope Peptides and Conjugation with Mannan","year":2021,"lang":"en","type":"review","venue":"Brain Sciences","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Epitope; Experimental autoimmune encephalomyelitis; Multiple sclerosis; Mannan; Immunotherapy; Immunology; Myelin basic protein; Peptide; Immune system; Antigen; Myelin; Chemistry; Biology; Medicine; Biochemistry; Neuroscience; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001903287,0.000388253,0.0002358854,0.0002387972,0.0001443874,0.0002592064,0.0002590849,0.0004525004,0.0009888927],"category_scores_gemma":[0.00007913593,0.0001184411,0.0003106685,0.000179679,0.0002597168,0.0004275086,0.0002858467,0.0005227821,0.0002982282],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630988,"about_ca_system_score_gemma":0.0001987229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001644778,"about_ca_topic_score_gemma":0.000219057,"domain_scores_codex":[0.9999112,0.00002627047,0.000005428845,0.00001715262,0.00002041409,0.00001954618],"domain_scores_gemma":[0.9999726,0.00000651069,0.000008191124,0.000002622066,0.000003796207,0.000006212402],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001692213,0.0001774695,0.0001201812,0.0009526779,0.00002781748,0.0004023081,0.0001224004,0.001278231,0.9571901,0.006256147,0.0003733354,0.0329301],"study_design_scores_gemma":[0.00007646131,0.003931963,0.001284815,0.0001168075,0.00006656284,0.001747161,0.00008615358,0.002626117,0.892581,0.002969849,0.09446007,0.00005296836],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.6871966,0.2069887,0.0743755,0.002114547,0.0007470978,0.0007423174,0.0002188912,0.000351704,0.0272646],"genre_scores_gemma":[0.8475061,0.092988,0.04290971,0.00072404,0.0002665546,0.0004505715,0.000193216,0.00005380822,0.01490805],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.0009888927,"threshold_uncertainty_score":0.003308177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1530314867452873,"score_gpt":0.3091574609769107,"score_spread":0.1561259742316234,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}