{"id":"W3217776441","doi":"10.1093/neuonc/noab196.072","title":"BIOM-41. LIVE-CELL IMAGING SHOWS UNEVEN SEGREGATION OF EXTRACHROMOSOMAL DNA ELEMENTS AND TRANSCRIPTIONALLY ACTIVE EXTRACHROMOSOMAL DNA CLUSTERS IN CANCER","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Extrachromosomal DNA; Biology; Mitosis; DNA; Carcinogenesis; Cell biology; Genetics; Cell; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001340621,0.0001955764,0.0001462705,0.0003229343,0.0002282345,0.0003692338,0.000176211,0.0003823723,0.001507943],"category_scores_gemma":[0.0001009076,0.0002101959,0.0001264553,0.0002957072,0.0002216443,0.0002222067,0.0002647139,0.0004388232,0.0004732407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209105,"about_ca_system_score_gemma":0.0002137224,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00177288,"about_ca_topic_score_gemma":0.002818481,"domain_scores_codex":[0.9999092,0.00000795981,0.000005321967,0.0000366358,0.00002205707,0.000018854],"domain_scores_gemma":[0.9999318,0.00002035774,0.00001330642,0.00001002219,0.000008707815,0.0000157958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001996115,0.000006308975,0.0002259505,0.00002551551,0.000002824806,0.00004497838,0.00002424031,0.0001050531,0.9981099,0.0001744372,0.0000465915,0.001214204],"study_design_scores_gemma":[0.000005609728,0.00004875459,0.00787277,0.000007403556,0.000009169352,0.0003191155,0.00004258153,0.003586171,0.9842719,0.0001756655,0.003653856,0.000007034135],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9535231,0.003446653,0.03480761,0.0003204127,0.00005358096,0.0000326065,0.000825491,0.0005056143,0.006484893],"genre_scores_gemma":[0.9720605,0.001254784,0.01871772,0.0001041827,0.000006878476,0.0000432486,0.0007001671,0.00009251408,0.007020001],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00177288,"threshold_uncertainty_score":0.00504458,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218851380799904,"score_gpt":0.2702314422739751,"score_spread":0.258042928465976,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}