{"id":"W3217779163","doi":"10.1080/19420862.2021.1999194","title":"Isolation and characterization of monoclonal antibodies against human carbonic anhydrase-IX","year":2021,"lang":"en","type":"article","venue":"mAbs","topic":"Enzyme function and inhibition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Terry Fox Research Institute; National Research Council Canada","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Cancer Research Institute","keywords":"Monoclonal antibody; Extracellular; Antibody; Carbonic anhydrase; Cancer cell; Enzyme; Tumor microenvironment; Cancer; Biochemistry; Biology; Chemistry; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001984733,0.0002602658,0.0001094484,0.0002325597,0.0001100002,0.0001886427,0.0001541179,0.0002058219,0.0005780144],"category_scores_gemma":[0.0003456057,0.00009902356,0.0001513098,0.0001211957,0.00009060761,0.0001100032,0.0001118142,0.0003548358,0.0003892464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003159621,"about_ca_system_score_gemma":0.0002816877,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001006503,"about_ca_topic_score_gemma":0.001411933,"domain_scores_codex":[0.9999171,0.00001105458,0.0000084677,0.00001764425,0.00002875019,0.00001694517],"domain_scores_gemma":[0.9999008,0.00001948794,0.00001619292,0.0000103551,0.0000305535,0.00002263545],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001171464,0.00001348165,0.000109617,0.00001768173,0.000002839485,0.00002309867,0.000008205667,0.00005851579,0.997792,0.00008275456,0.00005039175,0.001829791],"study_design_scores_gemma":[0.000028069,0.0001818282,0.006130991,0.000007779938,0.0000216783,0.0003985401,0.00001284893,0.0008943654,0.980456,0.00008259896,0.01178077,0.000004599133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9397171,0.006514433,0.04588122,0.0005804346,0.0001062299,0.0003571176,0.001406424,0.0001515024,0.00528565],"genre_scores_gemma":[0.9495911,0.00389989,0.03387703,0.0002360992,0.00005857976,0.0001980613,0.005307224,0.00005735563,0.006774829],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001006503,"threshold_uncertainty_score":0.002292514,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00858304745555132,"score_gpt":0.2303279438099151,"score_spread":0.2217448963543638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}