{"id":"W3217784408","doi":"10.1093/neuonc/noab196.798","title":"TAMI-14. REDUCTION IN S. CEREVISIAE GROWTH AND CELL VIABILITY IN RESPONSE TO D-2-HYDROXYGLUTARATE ACCUMULATION IS DAMPENED BY GROWTH CONDITIONS PERMISSIVE OF OXIDATIVE PHOSPHORYLATION","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal","funders":"","keywords":"Viability assay; Biology; Yeast; Biochemistry; Oxidative phosphorylation; Cell growth; Saccharomyces cerevisiae; Mitochondrion; Isocitrate dehydrogenase; Glycolysis; Cell; Cell biology; Metabolism","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345162,0.0005107891,0.0003826795,0.0002127376,0.0001951271,0.0004555038,0.000512785,0.000294911,0.003754593],"category_scores_gemma":[0.0001148451,0.0002175345,0.0003599017,0.0002927087,0.000234646,0.0001275103,0.0004364247,0.0006911999,0.001162123],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003366648,"about_ca_system_score_gemma":0.0003328533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009110928,"about_ca_topic_score_gemma":0.001378673,"domain_scores_codex":[0.9997268,0.00004189581,0.00004456516,0.0000669725,0.00006998106,0.00004979865],"domain_scores_gemma":[0.9998098,0.00003337503,0.00004152623,0.00003792888,0.00001862766,0.00005880308],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002299836,0.00007044383,0.00011559,0.00003771039,0.000006853003,0.00005168005,0.00001682612,0.00003209805,0.9982914,0.0001016161,0.00008320902,0.0009624404],"study_design_scores_gemma":[0.00003035324,0.0003721041,0.004172796,0.0000129348,0.00001474368,0.0001711919,0.00005847594,0.0008038176,0.9883022,0.00005413196,0.005998547,0.000008658893],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9818087,0.001307213,0.006141675,0.0003491527,0.0002584144,0.0001222678,0.004249894,0.0004437083,0.005318955],"genre_scores_gemma":[0.9713415,0.0008401197,0.01000069,0.0001897012,0.00002596103,0.0002339465,0.006452049,0.0002564648,0.01065961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003754593,"threshold_uncertainty_score":0.01256037,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01271525223825152,"score_gpt":0.2933964785730697,"score_spread":0.2806812263348181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}