{"id":"W3217786205","doi":"10.1161/circ.144.suppl_1.12932","title":"Abstract 12932: An Epigenetic Upregulation of Dynamin 2, a Regulator of Mitochondrial Fission, Promotes Human and Experimental Pulmonary Arterial Hypertension","year":2021,"lang":"en","type":"article","venue":"Circulation","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"","keywords":"Mitochondrial fission; DNM1L; Dynamin; Gene silencing; Medicine; Cell biology; Mitochondrion; Pathology; Cancer research; Biology; Cell; Endocytosis; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001380829,0.0003351408,0.0003460356,0.0002094397,0.0002048922,0.0002135308,0.0001668824,0.000358928,0.004802347],"category_scores_gemma":[0.0001202259,0.0001660328,0.0002865693,0.0001722142,0.0003308771,0.0001687995,0.0002532957,0.0007662322,0.0006797265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001842163,"about_ca_system_score_gemma":0.0002368059,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004379447,"about_ca_topic_score_gemma":0.0008633857,"domain_scores_codex":[0.999859,0.00001819951,0.00001095023,0.00005213196,0.00003631821,0.00002341213],"domain_scores_gemma":[0.999935,0.000006960126,0.00002293881,0.000007424222,0.000006274944,0.00002131686],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004281165,0.00005851226,0.0003576982,0.0001529654,0.00001943462,0.0001895383,0.00003505889,0.00007820902,0.9943596,0.0002593248,0.0004798838,0.003581676],"study_design_scores_gemma":[0.0004901977,0.002201966,0.02647025,0.00008409127,0.0001845781,0.002691811,0.0001842686,0.002617968,0.9339792,0.0006178057,0.03043718,0.00004060734],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983176,0.003902759,0.004909826,0.0006927603,0.0003237592,0.00008808971,0.002545866,0.0004882254,0.003872783],"genre_scores_gemma":[0.9908674,0.001153491,0.001135889,0.0001972649,0.0000319748,0.0001134807,0.0008231862,0.00005974631,0.005617546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004802347,"threshold_uncertainty_score":0.01606548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01640317344120617,"score_gpt":0.2555286183055906,"score_spread":0.2391254448643844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}