{"id":"W3217795007","doi":"10.1093/neuonc/noab196.719","title":"EXTH-80. PBI-200: IN VIVO EFFICACY OF A NOVEL, HIGHLY CNS-PENETRANT NEXT GENERATION TRK INHIBITOR","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Trk receptor; In vivo; Pharmacology; Medicine; Potency; Cancer research; In vitro; Biology; Internal medicine; Receptor; Neurotrophin; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002481858,0.0006311475,0.0005132295,0.0003247874,0.0001342517,0.0003281535,0.0004141639,0.0005006018,0.002337788],"category_scores_gemma":[0.0001069846,0.0001909495,0.0002430761,0.0002089201,0.0002457338,0.0003920887,0.0001217549,0.00153374,0.000849722],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005075751,"about_ca_system_score_gemma":0.0006440348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001775065,"about_ca_topic_score_gemma":0.002479434,"domain_scores_codex":[0.9998609,0.00002574809,0.000007052925,0.00003066013,0.00002886665,0.00004683706],"domain_scores_gemma":[0.9999273,0.00001116642,0.00001215723,0.000008172472,0.00000793903,0.00003326661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006782879,0.004558335,0.0003367591,0.0001664464,0.00005769137,0.0001149364,0.00005177446,0.00132365,0.9642664,0.0002548932,0.00236403,0.01972212],"study_design_scores_gemma":[0.001979315,0.03410434,0.004768405,0.0000147345,0.00009023024,0.000466911,0.00003028016,0.004625972,0.9494373,0.00009833232,0.004357175,0.00002708245],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9869925,0.00187383,0.002213935,0.0002744921,0.0001156361,0.0002505821,0.002008771,0.000602462,0.005667888],"genre_scores_gemma":[0.9858088,0.001423536,0.002557908,0.0001815136,0.00003302807,0.0002737046,0.003251735,0.00007422959,0.00639559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002337788,"threshold_uncertainty_score":0.007820666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05111894012264943,"score_gpt":0.3117298043116097,"score_spread":0.2606108641889603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}