{"id":"W3217795007","doi":"10.1093/neuonc/noab196.719","title":"EXTH-80. PBI-200: IN VIVO EFFICACY OF A NOVEL, HIGHLY CNS-PENETRANT NEXT GENERATION TRK INHIBITOR","year":2021,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Cancer Mechanisms and Therapy","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Paraza Pharma (Canada)","funders":"","keywords":"Trk receptor; In vivo; Pharmacology; Medicine; Potency; Cancer research; In vitro; Biology; Internal medicine; Receptor; Neurotrophin; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001729291,0.0001740595,0.0005579364,0.0001546316,0.00003689469,0.0000128627,0.00008099587,0.0002200753,0.0006800047],"category_scores_gemma":[0.000123218,0.0001674366,0.0001195761,0.0003729135,0.00005322064,0.00006820999,0.00004042504,0.000291004,0.00001182269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002041755,"about_ca_system_score_gemma":0.0006885706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001220591,"about_ca_topic_score_gemma":0.0006438163,"domain_scores_codex":[0.9984481,0.000115408,0.0004965207,0.0004241859,0.0002255868,0.0002902121],"domain_scores_gemma":[0.9990872,0.0001863537,0.0001374385,0.0003349597,0.0001327544,0.0001213227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005812997,0.001031013,0.0001491833,0.00003101034,0.00002574668,0.0003873269,0.0004814202,0.00005993959,0.9777113,0.001119272,0.001524859,0.01689762],"study_design_scores_gemma":[0.01061468,0.002131178,0.0008917704,0.00004737537,0.00005567137,0.0002620885,0.0001018825,0.0010542,0.8312049,0.00004342966,0.1534481,0.0001447051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918522,0.0007281745,0.0006771554,0.003359417,0.00178448,0.0004385536,0.00001620091,0.00003595867,0.001107885],"genre_scores_gemma":[0.9923624,0.0004977783,0.00195286,0.003881741,0.001040768,0.00004535413,0.00002551397,0.0000400115,0.0001535267],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1519233,"threshold_uncertainty_score":0.7445574,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05111894012264943,"score_gpt":0.3117298043116097,"score_spread":0.2606108641889603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}