{"id":"W3217805933","doi":"10.1136/bmjopen-2021-052450","title":"Randomised controlled trial comparing rituximab to mycophenolate mofetil in children and young adults with steroid-dependent idiopathic nephrotic syndrome: study protocol","year":2021,"lang":"en","type":"article","venue":"BMJ Open","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Ministero della Salute; Ospedale Pediatrico Bambino Gesù","keywords":"Medicine; Rituximab; Calcineurin; Nephrotic syndrome; Mycophenolate; Clinical endpoint; Cyclophosphamide; Pediatrics; Internal medicine; Clinical trial; Transplantation; Lymphoma; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007277166,0.004510752,0.01010961,0.0008988078,0.001205599,0.002554114,0.002175633,0.004514055,0.04459424],"category_scores_gemma":[0.008478611,0.00158597,0.004166226,0.001439701,0.00188708,0.00214357,0.001130439,0.003781521,0.005957916],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002465194,"about_ca_system_score_gemma":0.006369993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735211,"about_ca_topic_score_gemma":0.003825414,"domain_scores_codex":[0.9956354,0.002363379,0.000488975,0.0006118081,0.0003594855,0.0005408453],"domain_scores_gemma":[0.9967183,0.0009300394,0.000954635,0.0002996067,0.0004600628,0.0006373854],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9725245,0.003138317,0.0004975657,0.009666342,0.002690051,0.00009222738,0.00007360851,0.0004363588,0.0006131087,0.0005308904,0.00331077,0.006426394],"study_design_scores_gemma":[0.9822409,0.01102096,0.0008188095,0.0005886936,0.0009793144,0.00002667468,0.00002445956,0.0002727949,0.0001129666,0.0003742203,0.003513806,0.00002637858],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"protocol","genre_gemma":"protocol","genre_scores_codex":[0.05665632,0.007890824,0.002655556,0.001572751,0.002319336,0.9160678,0.007793361,0.0002414852,0.004802541],"genre_scores_gemma":[0.0666746,0.003259785,0.00341305,0.00171229,0.0005504018,0.9180449,0.001941476,0.00002430777,0.004379231],"genre_candidate":"protocol","genre_consensus":"protocol","teacher_disagreement_score":0.04459424,"threshold_uncertainty_score":0.1491827,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02288892441459421,"score_gpt":0.3387143275822228,"score_spread":0.3158254031676285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}